Phytomedicines Targeting Cancer Stem Cells: Therapeutic Opportunities and Prospects for Pharmaceutical Development

被引：12

作者：

Gupta, Piyush Kumar ^{[1
]}

Saraff, Mrunmayee ^{[2
]}

Gahtori, Rekha ^{[3
]}

Negi, Nidhi ^{[4
]}

Tripathi, Surya Kant ^{[5
]}

Kumar, Jatin ^{[1
]}

Kumar, Sanjay ^{[1
]}

Aldhayan, Saad Hamad ^{[6
]}

Dhanasekaran, Sugapriya ^{[7
]}

Abomughaid, Mosleh Mohammad ^{[7
]}

Dua, Kamal ^{[8
]}

Gundamaraju, Rohit ^{[9
]}

Ojha, Shreesh ^{[10
]}

Ruokolainen, Janne ^{[11
]}

Jha, Niraj Kumar ^{[12
]}

Kesari, Kavindra Kumar ^{[11
,13
]}

机构：

[1] Sharda Univ, Sch Basic Sci & Res SBSR, Dept Life Sci, Knowledge Pk 3, Greater Noida 201310, Uttar Pradesh, India

[2] St Xaviers Coll Autonomous, Dept Microbiol, Mumbai 400001, Maharashtra, India

[3] Kumaun Univ, Dept Biotechnol, Sir JC Bose Tech Campus, Naini Tal 263136, Uttarakhand, India

[4] Kumaun Univ, Dept Chem, DSB Campus, Naini Tal 263001, Uttarakhand, India

[5] Natl Inst Technol, Dept Life Sci, Canc Drug Resistance Lab, Rourkela 769008, Odisha, India

[6] Prince Sultan Mil Med City, Pharmaceut Dept, Riyadh 12233, Saudi Arabia

[7] Univ Bisha, Coll Appl Med Sci, Med Lab Sci Dept, Bisha 67714, Saudi Arabia

[8] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia

[9] Univ Tasmania, Sch Hlth Sci, ER Stress & Mucosal Immunol Lab, Launceston, Tas 7248, Australia

[10] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, POB 17666, Al Ain 15551, U Arab Emirates

[11] Aalto Univ, Sch Sci, Dept Appl Phys, Espoo 00076, Finland

[12] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India

[13] Aalto Univ, Sch Chem Engn, Dept Bioprod & Biosyst, Espoo 00076, Finland

来源：

PHARMACEUTICALS | 2021年 / 14卷 / 07期

关键词：

phytomedicines; phytochemicals; stem cells; signaling pathway; epithelial-mesenchymal transition; preclinical; clinical research; EPITHELIAL-MESENCHYMAL TRANSITION; NATURAL DIETARY COMPOUND; MOLECULAR-MECHANISM; GLIOBLASTOMA CELLS; PANCREATIC-CANCER; SIDE POPULATION; SELF-RENEWAL; IN-VITRO; INHIBITION; APOPTOSIS;

D O I：

10.3390/ph14070676

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The presence of small subpopulations of cells within tumor cells are known as cancer stem cells (CSCs). These cells have been the reason for metastasis, resistance with chemotherapy or radiotherapy, and tumor relapse in several types of cancers. CSCs underwent to epithelial-mesenchymal transition (EMT) and resulted in the development of aggressive tumors. CSCs have potential to modulate numerous signaling pathways including Wnt, Hh, and Notch, therefore increasing the stem-like characteristics of cancer cells. The raised expression of drug efflux pump and suppression of apoptosis has shown increased resistance with anti-cancer drugs. Among many agents which were shown to modulate these, the plant-derived bioactive agents appear to modulate these key regulators and were shown to remove CSCs. This review aims to comprehensively scrutinize the preclinical and clinical studies demonstrating the effects of phytocompounds on CSCs isolated from various tumors. Based on the available convincing literature from preclinical studies, with some clinical data, it is apparent that selective targeting of CSCs with plants, plant preparations, and plant-derived bioactive compounds, termed phytochemicals, may be a promising strategy for the treatment of relapsed cancers.

引用

页数：25

共 81 条

[81] miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells [J].

Zhu, Jianyun ;

Wang, Shijia ;

Chen, Yue ;

Li, Xiaoting ;

Jiang, Ye ;

Yang, Xue ;

Li, Yuan ;

Wang, Xiaoqian ;

Meng, Yu ;

Zhu, Mingming ;

Ma, Xiao ;

Huang, Cong ;

Wu, Rui ;

Xie, Chunfeng ;

Geng, Shanshan ;

Wu, Jieshu ;

Zhong, Caiyun ;

Han, Hongyu .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2017, 44 :80-91

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