The quantification of blood-brain barrier disruption using dynamic contrast-enhanced magnetic resonance imaging in aging rhesus monkeys with spontaneous type 2 diabetes mellitus

被引：37

作者：

Xu, Ziqian ^{[1
]}

Zeng, Wen ^{[2
]}

Sun, Jiayu ^{[1
]}

Chen, Wei ^{[1
]}

Zhang, Ruzhi ^{[1
]}

Yang, Zunyuan ^{[2
]}

Yao, Zunwei ^{[2
]}

Wang, Lei ^{[1
]}

Song, Li ^{[1
]}

Chen, Yushu ^{[1
]}

Zhang, Yu ^{[1
]}

Wang, Chunhua ^{[1
]}

Gong, Li ^{[2
]}

Wu, Bing ^{[1
]}

Wang, Tinghua ^{[3
,4
]}

Zheng, Jie ^{[5
]}

Gao, Fabao ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Radiol, Chengdu, Sichuan, Peoples R China

[2] Sichuan Primed Biotech Grp Co Ltd, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Dept Anesthesiol, Chengdu, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp, Translat Neurosci Ctr, Inst Neurol Dis, Chengdu, Sichuan, Peoples R China

[5] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA

来源：

NEUROIMAGE | 2017年 / 158卷

基金：

中国国家自然科学基金;

关键词：

Blood-brain barrier (BBB); Type 2 diabetes mellitus (T2DM); Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI); Extended Tofts model; K-trans; ARTERIAL INPUT FUNCTIONS; MULTIPLE-SCLEROSIS; PARTIAL VOLUME; GRADIENT-ECHO; IN-VIVO; DCE-MRI; PERMEABILITY; DISEASE; MODEL; PERFUSION;

D O I：

10.1016/j.neuroimage.2016.07.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microvascular lesions of the body are one of the most serious complications that can affect patients with type 2 diabetes mellitus. The blood-brain barrier (BBB) is a highly selective permeable barrier around the microvessels of the brain. This study investigated BBB disruption in diabetic rhesus monkeys using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Multi-slice DCE-MRI was used to quantify BBB permeability. Five diabetic monkeys and six control monkeys underwent magnetic resonance brain imaging in 3 Tesla MRI system. Regions of the frontal cortex, the temporal cortex, the basal ganglia, the thalamus, and the hippocampus in the two groups were selected as regions of interest to calculate the value of the transport coefficient K-trans using the extended Tofts model. Permeability in the diabetic monkeys was significantly increased as compared with permeability in the normal control monkeys. Histopathologically, zonula occludens protein-1 decreased, immunoglobulin G leaked out of the blood, and nuclear factor E2-related factor translocated from the cytoplasm to the nuclei. It is likely that diabetes contributed to the increased BBB permeability.

引用

页码：480 / 487

页数：8

共 54 条

[1] Structure and function of the blood-brain barrier [J].

Abbott, N. Joan ;

Patabendige, Adjanie A. K. ;

Dolman, Diana E. M. ;

Yusof, Siti R. ;

Begley, David J. .

NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25

[2] Diabetes, Alzheimer disease, and vascular dementia A population-based neuropathologic study [J].

Ahtiluoto, S. ;

Polvikoski, T. ;

Peltonen, M. ;

Solomon, A. ;

Tuomilehto, J. ;

Winblad, B. ;

Sulkava, R. ;

Kivipelto, M. .

NEUROLOGY, 2010, 75 (13) :1195-1202

[3] Magnetic Resonance Imaging Profile of Blood-Brain Barrier Injury in Patients With Acute Intracerebral Hemorrhage [J].

Aksoy, Didem ;

Bammer, Roland ;

Mlynash, Michael ;

Venkatasubramanian, Chitra ;

Eyngorn, Irina ;

Snider, Ryan W. ;

Gupta, Sandeep N. ;

Narayana, Rashmi ;

Fischbein, Nancy ;

Wijman, Christine A. C. .

JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2013, 2 (03)

[4] Blood-Brain Barrier and Traumatic Brain Injury [J].

Alves, Jose Luis .

JOURNAL OF NEUROSCIENCE RESEARCH, 2014, 92 (02) :141-147

[5] Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease [J].

Argaw, Azeb Tadesse ;

Asp, Linnea ;

Zhang, Jingya ;

Navrazhina, Kristina ;

Trinh Pham ;

Mariani, John N. ;

Mahase, Sean ;

Dutta, Dipankar J. ;

Seto, Jeremy ;

Kramer, Elisabeth G. ;

Ferrara, Napoleone ;

Sofroniew, Michael V. ;

John, Gareth R. .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (07) :2454-2468

[6]

Barnes S. R., 2015, MAGN RESON MED

[7] Differential microstructure and physiology of brain and bone metastases in a rat breast cancer model by diffusion and dynamic contrast enhanced MRI [J].

Budde, Matthew D. ;

Gold, Eric ;

Jordan, E. Kay ;

Frank, Joseph A. .

CLINICAL & EXPERIMENTAL METASTASIS, 2012, 29 (01) :51-62

[8] Blood-Brain Barrier Pathophysiology in Traumatic Brain Injury [J].

Chodobski, Adam ;

Zink, Brian J. ;

Szmydynger-Chodobska, Joanna .

TRANSLATIONAL STROKE RESEARCH, 2011, 2 (04) :492-516

[9] Abnormal blood-brain barrier permeability in normal appearing white matter in multiple sclerosis investigated by MRI [J].

Cramer, S. P. ;

Simonsen, H. ;

Frederiksen, J. L. ;

Rostrup, E. ;

Larsson, H. B. W. .

NEUROIMAGE-CLINICAL, 2014, 4 :182-189

[10] Permeability of the blood-brain barrier predicts conversion from optic neuritis to multiple sclerosis [J].

Cramer, Stig P. ;

Modvig, Signe ;

Simonsen, Helle J. ;

Frederiksen, Jette L. ;

Larsson, Henrik B. W. .

BRAIN, 2015, 138 :2571-2583

← 1 2 3 4 5 6 →