Absolute configuration of the fungal metabolite spirolaxine

被引：23

作者：

Bava, A

Clericuzio, M

Giannini, G

Malpezzi, L

Meille, SV

Nasini, G

机构：

[1] CNR, ICRM, Dipartimento Chim Mat & Ingn Chim Politecn, I-20131 Milan, Italy

[2] Univ Turin, Dipartimento Chim Gen & Organ Applicata, I-10125 Turin, Italy

[3] Sigma Tau Pharmaceut Co, Res & Dev, I-00040 Pomezia, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 11期

关键词：

basidiomycetes; secondary metabolite; absolute configuration; circular dichroism; angiogenesis; spiro compounds;

D O I：

10.1002/ejoc.200400902

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations. (c) Wiley-VCH Verlag GmbH & Co.

引用

页码：2292 / 2296

页数：5

共 21 条

[11] USE OF CNDO METHOD IN SPECTROSCOPY .4. SMALL MOLECULES - SPECTRA AND GROUND-STATE PROPERTIES [J].