Absolute configuration of the fungal metabolite spirolaxine

被引：23
作者：
Bava, A
Clericuzio, M
Giannini, G
Malpezzi, L
Meille, SV
Nasini, G
机构：
[1] CNR, ICRM, Dipartimento Chim Mat & Ingn Chim Politecn, I-20131 Milan, Italy
[2] Univ Turin, Dipartimento Chim Gen & Organ Applicata, I-10125 Turin, Italy
[3] Sigma Tau Pharmaceut Co, Res & Dev, I-00040 Pomezia, Italy
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 11期
关键词：
basidiomycetes; secondary metabolite; absolute configuration; circular dichroism; angiogenesis; spiro compounds;
D O I：
10.1002/ejoc.200400902
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The relative stereochemistry of the four stereocentres of spirolaxine 1, a bioactive 6,5-spiroacetal phthalide secondary metabolite, was determined through single-crystal X-ray analysis. Its absolute configuration was determined by circular dichroism; the experimental spectrum of spirolaxine is in good agreement with that evaluated by means of DeVoe coupled-oscillator calculations. (c) Wiley-VCH Verlag GmbH & Co.
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收藏
页码：2292 / 2296
页数：5
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