Effect of 1-butanol on the microstructure of lecithin/water/tripalmitin system

被引：32
作者：
Caboi, F
Lazzari, P
Pani, L
Monduzzi, M
机构：
[1] Neurosci PharmaNess Scarl, I-09123 Cagliari, Italy
[2] Univ Cagliari, CSGI, Dipartimento Sci Chim, I-09042 Monserrato, CA, Italy
[3] CNR, Inst Neurogenet & Neuropharmacol, I-09047 Selargius, CA, Italy
来源：
CHEMISTRY AND PHYSICS OF LIPIDS | 2005年 / 135卷 / 02期
关键词：
lecithin; glyceryl tripalmitate; phase behavior; warm microemulsion; NMR PGSE;
D O I：
10.1016/j.chemphyslip.2005.02.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Warm microemulsions based on lipids characterized by a melting point over 50 degrees C have been successfully used as starting matrix in a quenching process to obtain solid lipid nanoparticles (SLN). In this work, we have investigated the effect of 1-butanol (B) on the phase behavior of the lecithin (LCT)/water(W)/tripalmitin (TP) system at 70 degrees C. The study has been carried out at LCT/B=1 (weight ratio). Emulsion and liquid crystalline phase regions have been observed in the ternary phase diagram, while the presence of 1-butanol in the LCT/W/B/TP system allows the formation of a wide area of liquid isotropic phase from the whole (LCT+B)/TP binary axis up to 37 wt% of water. The microstructure of this isotropic phase has been investigated by means of H-1 NMR PGSE technique. The self-diffusion coefficients of the different components along oil and water dilution lines indicate a microstructural organization characterized by a highly connected water in oil domains. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：147 / 156
页数：10
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