Studies on uracils:: A facile one-pot synthesis of pyrazolo[3,4-d]pyrimidines

被引：8

作者：

Bhuyan, PJ ^{[1
]}

Borah, HN ^{[1
]}

Lekhok, KC ^{[1
]}

Sandhu, JS ^{[1
]}

机构：

[1] Reg Res Lab, Jorhat 785006, Assam, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 38卷 / 02期

关键词：

D O I：

10.1002/jhet.5570380230

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 6-hydrazino uracils 1 and nitrones 2 result in an efficient one-pot synthesis of pyrazolo[3,4-d]pyrimidines 3 in excellent yields. The isolation of the by-product aniline from the reaction mixture supported the plausible mechanism for the formation of pyrazolo[3,4-d]pyrimidines.

引用

收藏

页码：491 / 493

页数：3

相关论文

共 30 条

[1] Studies on uracils:: Synthesis of novel uracil analogues via 1,5- and 1,6-intramolecular cycloaddition reactions [J].

Bhuyan, PJ ;

Lekhok, KC ;

Sandhu, JS .

JOURNAL OF CHEMICAL RESEARCH-S, 1998, (09) :502-503

[2] ''Tertiary amine effect'' strategy in the synthesis of novel uracil analogues [J].

Bhuyan, PJ ;

Sandhu, JS ;

Ghosh, AC .

TETRAHEDRON LETTERS, 1996, 37 (11) :1853-1854

[3] Studies on uracils:: Synthesis of tetrazolo[4′,5′:1,6] pyrido[2,3-d]pyrimidines by the action of cyano stabilised carbanions on 6-azido-5-formyluracils [J].

Bhuyan, PJ ;

Lekhok, KC ;

Sandhu, JS .

JOURNAL OF CHEMICAL RESEARCH-S, 1999, (03) :232-233

[4] Studies on uracils:: an efficient method for the synthesis of novel 1-allyl-6-(1′,2′,3′-triazolyl) analogues of HEPT [J].

Bhuyan, PJ ;

Borah, HN ;

Sandhu, JS .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (21) :3083-3084

[5]

BOOTH BA, 1961, J BIOL CHEM, V236, P203

[6]

Brown D. J., 1984, Comprehensive Heterocyclic Chemistry, V1, P57

[7]

DECLERCQ E, 1987, J BIOL CHEM, V262, P14905

[8] ARYLIDENEMALONONITRILES IN HETEROCYCLIC SYNTHESES - A NOVEL SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES [J].

GOGOI, M ;

BHUYAN, P ;

SANDHU, JS ;

BARUAH, JN .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (23) :1549-1550

[9] 2'-FLUORINATED ARABINONUCLEOSIDES OF 5-(2-HALOALKYL)URACIL - SYNTHESIS AND ANTIVIRAL ACTIVITY [J].

GRIENGL, H ;

WANEK, E ;

SCHWARZ, W ;

STREICHER, W ;

ROSENWIRTH, B ;

DECLERCQ, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (07) :1199-1204

[10] PYRIMIDINES .53. NOVEL RING TRANSFORMATION INDUCED BY THE SUBSTITUENT EFFECT OF THE PHENYL GROUP - REACTION OF 5-BROMO-6-METHYL-1-PHENYLURACIL DERIVATIVES WITH AMINES AND HYDRAZINE TO GIVE HYDANTOINS AND PYRAZOLONES [J].

HIROTA, K ;

BANNO, K ;

YAMADA, Y ;

SENDA, S .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1985, (06) :1137-1142