Identification of blood microRNAs associated to Parkinsonis disease

被引:211
作者
Margis, Regina [2 ,3 ]
Margis, Rogerio [1 ,3 ]
Rieder, Carlos R. M. [2 ]
机构
[1] Univ Fed Rio Grande do Sul, Ctr Biotechnol, Av Bento Goncalves 9500,Predio 43431,Sala 213,CxP, BR-91501970 Porto Alegre, RS, Brazil
[2] Hosp Clin Porto Alegre, Neurol Sect, Movement Disorders Unit, BR-9003500 Porto Alegre, RS, Brazil
[3] VITATEC Cons Des Biotecnol Ltda, BR-91010005 Porto Alegre, RS, Brazil
关键词
Parkinson's disease; MicroRNA; Neurodegenerative disease; RT-qPCR; Molecular marker; MINI-MENTAL-STATE; ALPHA-SYNUCLEIN; NEURODEGENERATIVE DISEASES; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; PROTEIN TPPP/P25; GENE-EXPRESSION; BRAIN; MECHANISM; TARGETS;
D O I
10.1016/j.jbiotec.2011.01.023
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The present study demonstrates that blood samples can be used as a source of miRNA identification associated to Parkinson's disease (PD). A set of six differentially expressed microRNAs were identified. They form two groups according to their expression profile in control, non-treated, early-onset and treated Parkinson's disease subjects. While miR-1, miR-22* and miR-29 expression levels allowed to distinguish non-treated PD from healthy subjects, miR-16-2*, miR-26a2* and miR30a differentiated treated from untreated patients. This study is innovative in contributing to the development of effective PD biomarkers. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:96 / 101
页数:6
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