Does inflammatory acne result from imbalance in the keratinocyte innate immune response?

被引：18

作者：

Grange, Philippe A. ^{[2
]}

Weill, Bernard ^{[1
]}

Dupin, Nicolas ^{[2
,3
]}

Batteux, Frederic ^{[1
,4
]}

机构：

[1] Univ Paris 05, Fac Med, EA 1833, Immunol Lab, F-75679 Paris 14, France

[2] Univ Paris 05, Fac Med, EA 1833, Lab Rech Dermatol, F-75679 Paris 14, France

[3] Hop Cochin, AP HP, Serv Dermatol Venereol, F-75006 Paris, France

[4] Univ Paris 05, Fac Med, ERTi, F-75679 Paris 14, France

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 14-15期

关键词：

Propionibacterium acnes; Inflammation; Oxidative stress; Innate immunity; Skin; TOLL-LIKE RECEPTOR-2; 16S RIBOSOMAL-RNA; PROPIONIBACTERIUM-ACNES; SUPEROXIDE-DISMUTASE; REACTIVE OXYGEN; P-ACNES; EXPRESSION; ACTIVATION; GENERATION; INDUCTION;

D O I：

10.1016/j.micinf.2010.07.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acne is a multifactorial chronic disease affecting around 80% of teenage population. The pathogenesis of acne involves inflammatory reactions and colonization by the Propionibacterium acnes (P. acnes) strain. P acnes stimulates the keratinocytes involved in the innate immune response, the intensity of which could be influenced either by bacterial intrinsic factors or by endogenous factors of the host. (C) 2010 Published by Elsevier Masson SAS on behalf of Institut Pasteur.

引用

页码：1085 / 1090

页数：6

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