Nucleoside analogues as anticancer agents

被引：0
作者：
Wu, YW [1 ]
Jiang, YW [1 ]
Fu, H [1 ]
Yang, J [1 ]
Zhao, YF [1 ]
机构：
[1] Tsinghua Univ, Dept Chem, Minsist Educ, Sch Life Sci & Engn,Key Lab Bioorgan Phosphorus C, Beijing 100084, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 23卷 / 10期
关键词：
nucleoside anticancer agent; nucleoside analogue; IMPDH inhibitor; nucleoside phosphor-amidate;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The recent progress of nucleoside analogues as anticancer agents is reviewed. The mechanisms for the action of these nucleoside analogues and drug metabolism are introduced. Especially the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors are described. At last the relationship between the structure of nucleoside phosphoramidates and their anticancer activity is discussed.
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收藏
页码：1091 / 1098
页数：8
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