Chitosan nanoparticles for oral drug and gene delivery

被引：324
作者：
Bowman, Katherine [1 ]
Leong, Kam W. [1 ]
机构：
[1] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2006年 / 1卷 / 02期
关键词：
chitosan; oral delivery; nanoparticles;
D O I：
10.2147/nano.2006.1.2.117
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptake and promoting gene expression. This review summarizes some of these findings and highlights the potential of chitosan as a component of oral delivery systems.
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页码：117 / 128
页数：12
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