Modification of 1,2,4,5-tetrazine with cationic rhenium(I) polypyridine units to afford phosphorogenic bioorthogonal probes with enhanced reaction kinetics

被引：36
作者：
Choi, Alex Wing-Tat [1 ]
Tso, Karson Ka-Shun [1 ]
Yim, Vicki Man-Wai [1 ]
Liu, Hua-Wei [1 ]
Lo, Kenneth Kam-Wing [1 ]
机构：
[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon, Hong Kong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 16期
关键词：
CHEMISTRY; COMPLEXES; CELLS; TETRAZINES; BINDING;
D O I：
10.1039/c4cc09532d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New phosphorogenic bioorthogonal probes derived from mononuclear and binuclear rhenium(I) polypyridine complexes containing a 1,2,4,5-tetrazine moiety were designed; these complexes displayed substantial dienophile-induced emission enhancement, and accelerated reaction kinetics and could target a protein conjugate in living cells.
引用
收藏
页码：3442 / 3445
页数：4
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