Tea and cancer prevention: Molecular mechanisms and human relevance

被引:202
作者
Yang, Chung S.
Lambert, Joshua D.
Ju, Jihyeung
Lu, Gang
Sang, Shengmin
机构
[1] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Ernest Mario Sch Pharm, Ctr Canc Prevent Res, Piscataway, NJ 08854 USA
[3] Canc Inst New Jersey, New Brunswick, NJ 08901 USA
关键词
tea; camellia sinensis; cancer prevention; catechins; theaflavins;
D O I
10.1016/j.taap.2006.11.024
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tea made from the leaves of the plant Camellia sinensis is a popular beverage. The possible cancer-preventive activity of tea and tea polyphenols has been studied extensively. This article briefly reviews studies in animal models, cell lines, and possible relevance of these studies to the prevention of human cancer. The cancer-preventive activity of tea constituents have been demonstrated in many animal models including cancer of the skin, lung, oral cavity, esophagus, stomach, liver, pancreas, small intestine, colon, bladder, prostate, and mammary gland. The major active constituents are polyphenols, of which (-)-epigallocatechin-3-gallate (EGCG) is most abundant, most active, and most studied, and caffeine. The molecular mechanisms of the cancer-preventive action, however, are just beginning to be understood. Studies in cell lines led to the proposal of many mechanisms on the action of EGCG. However, mechanisms based on studies with very high concentrations of EGCG may not be relevant to cancer prevention in vivo. The autooxidation of EGCG in cell culture may also produce activities that do not occur in many internal organs. In contrast to the cancer prevention activity demonstrated in different animal models, no such conclusion can be convincingly drawn from epidemiological studies on tea consumption and human cancers. Even though the human data are inconclusive, tea constituents may still be used for the prevention of cancer at selected organ sites if sufficient concentrations of the agent can be delivered to these organs. Some interesting examples in this area are discussed. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:265 / 273
页数:9
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