Recent Progress in Benzylic C(sp3)-H Functionalization of Toluene and Its Derivatives

被引：5

作者：

Cai Chenyi ^{[1
]}

Zou Dong ^{[1
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Coll Med, Dept Pharm, Hangzhou 310013, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 42卷 / 06期

关键词：

toluene; C(sp(3))-H bond activation; inert; selective catalysis; C-X bonds formation; C-H BONDS; CATALYZED OXIDATIVE ESTERIFICATION; CARBOXYLIC-ACID DERIVATIVES; METAL-FREE; EFFICIENT SYNTHESIS; ACTIVATION; AMINATION; SILYLATION; ARYLATION; SP(3);

D O I：

10.6023/cjoc202201027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Toluene derivatives are alkyl aromatic hydrocarbons derived from oil and natural gas and are among the cheapest and most readily available materials for the chemical industry. C-H functionalization is important for the synthesis of various bioactive substances, and inert benzylic hydrocarbon bond activation has long been a big challenge in this field due to the high hydrocarbon bond energy. Therefore, the development of simple and efficient methods for C-C and C-X bonds formation has been demonstrated as one of the hot topics by activating the benzylic C(sp(3))-H bonds in recent years. The progress in benzylic C(sp(3))-H functionalization of toluene and its derivatives under different catalytic conditions in the past decade is summarized according to different reaction classifications. The reaction substrate compatibility, mechanism, applications, advantages and limitations in this field are also discussed in detail.

引用

页码：1586 / 1608

页数：23

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