Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

被引：375
|
作者：
Kriz, Wilhelm [1 ]
Kaissling, Brigitte [2 ]
Le Hir, Michel [2 ]
机构：
[1] Heidelberg Univ, Med Fak Mannheim, Abt Anat & Entwicklungsbiol, D-68167 Mannheim, Germany
[2] Univ Zurich, Inst Anat, Zurich, Switzerland
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 02期
关键词：
PROGRESSIVE TUBULOINTERSTITIAL FIBROSIS; SMOOTH-MUSCLE-CELLS; INTERSTITIAL FIBROSIS; LIVER FIBROSIS; GROWTH-FACTOR; MODEL; VIMENTIN; MYOFIBROBLASTS; EXPRESSION; DIFFERENTIATION;
D O I：
10.1172/JCI44595
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Epithelial-mesenchymal transition (EMT) has become widely accepted as a mechanism by which injured renal tubular cells transform into mesenchymal cells that contribute to the development of fibrosis in chronic renal failure. However, an increasing number of studies raise doubts about the existence of this process in vivo. Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking.
引用
收藏
页码：468 / 474
页数：7
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