A highly selective fluorescent probe for thiol bioimaging

被引：262
作者：
Bouffard, Jean [1 ,2 ]
Kim, Youngmi [1 ,2 ]
Swager, Timothy M. [1 ,2 ]
Weissleder, Ralph [1 ,2 ]
Hilderbrand, Scott A. [1 ,2 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA
[2] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 01期
关键词：
D O I：
10.1021/ol702539v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new fluorescent turn-on probe (3) for the selective sensing and bioimaging of thiols is reported. In aqueous buffer solutions at physiological pH, thiols cleave the 2,4-dinitrobenzenesulfonyl group to release the red-emissive donor-acceptor fluorophore (4). The probe displays excellent immunity to interference from nitrogen and oxygen nucleophiles and the imaging of thiols in living cells is demonstrated.
引用
收藏
页码：37 / 40
页数：4
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