Antibodies to GM1 and Gal(beta 1-3)GalNAc at the nodes of Ranvier in human and experimental autoimmune neuropathy

被引：0
作者：
Thomas, FP
机构：
[1] Department of Neurology, Institute for Molecular Virology, St. Louis University, St. Louis, MO
[2] Institute for Molecular Virology, St. Louis University, St. Louis, MO 63110-2592
来源：
MICROSCOPY RESEARCH AND TECHNIQUE | 1996年 / 34卷 / 06期
关键词：
autoantibodies; campylobacter; glycoproteins; gangliosides; GM1; neuropathy; nodes of Ranvier;
D O I：
10.1002/(SICI)1097-0029(19960815)34:6<536::AID-JEMT5>3.0.CO;2-H
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Autoantibodies to Gal(beta 1-S)GalNAc epitopes on glycolipids and glycoproteins are associated with motor neuron disease and motor or sensorimotor neuropathy. These epitopes are ubiquitously distributed on cell surfaces. In the nervous system they are present on axons and myelin, specifically also at the nodes of Ranvier. Binding of GM1 antibodies to the nodal area may contribute to disease development in some of these conditions. (C) 1996 Wiley-Liss, Inc.
引用
收藏
页码：536 / 543
页数：8
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