Application of Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine to the Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines

被引：71
作者：
Beng, Timothy K. [1 ]
Gawley, Robert E. [1 ]
机构：
[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 03期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
N-BOC-PYRROLIDINE; ENANTIOSELECTIVE SYNTHESIS; ALPHA-ARYLATION; DEPROTONATION; 2-ARYLPIPERIDINES; EFFICIENT;
D O I：
10.1021/ol102682r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The highly enantioselective synthesis of 2-aryl- and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.
引用
收藏
页码：394 / 397
页数：4
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