Application of Catalytic Dynamic Resolution of N-Boc-2-lithiopiperidine to the Asymmetric Synthesis of 2-Aryl and 2-Vinyl Piperidines

被引：72

作者：

Beng, Timothy K. ^{[1
]}

Gawley, Robert E. ^{[1
]}

机构：

[1] Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 03期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

N-BOC-PYRROLIDINE; ENANTIOSELECTIVE SYNTHESIS; ALPHA-ARYLATION; DEPROTONATION; 2-ARYLPIPERIDINES; EFFICIENT;

D O I：

10.1021/ol102682r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly enantioselective synthesis of 2-aryl- and 2-vinyl-piperidines has been accomplished through a catalytic dynamic resolution (CDR) of N-Boc-2-lithiopiperidine. The method has been applied to the synthesis of both enantiomers of the tobacco alkaloid anabasine.

引用

页码：394 / 397

页数：4

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