A Proof-of-Concept Study of an In-Situ Partial-Ring Time-of-Flight PET Scanner for Proton Beam Verification

Development of a positron emission tomography (PET) system capable of in-situ imaging requires a design that can accommodate the proton treatment beam nozzle. Among the several PET instrumentation approaches developed thus far, the dual-panel PET scanner is often used as it is simpler to develop and integrate within the proton therapy gantry. Partial-angle coverage of these systems can however lead to limited-angle artifacts in the reconstructed PET image. We have previously demonstrated via simulations that time-of-flight (TOF) reconstruction reduces the artifacts accompanying limited-angle data, and permits proton range measurement with 1-2 mm accuracy and precision. In this work, we show measured results from a small proof-of-concept dual-panel PET system that uses TOF information to reconstruct PET data acquired after proton irradiation. The PET scanner comprises of two detector modules, each composed of an array of 4x4x30 mm(3) lanthanum bromide scintillator. Measurements are performed with an oxygen-rich gel-water, an adipose tissue equivalent material, and in vitro tissue phantoms. For each phantom measurement, a 2-Gy dose was deposited using 54-100 MeV proton beams. For each phantom, a Monte Carlo simulation generating the expected distribution of PET isotope from the corresponding proton irradiation was also performed. The proton range was calculated by drawing multiple depth profiles over a central region encompassing the proton dose deposition. For each profile, the proton range was calculated using two techniques 1) 50% pick-off from the distal edge of the profile and 2) comparing the measured and Monte Carlo profile to minimize the absolute sum of differences over the entire profile. A 10-min PET acquisition acquired with minimal delay post proton irradiation is compared with a 10-min PET scan acquired after a 20-min delay. Measurements show that PET acquisition with minimal delay is necessary to collect O-15 signal, and maximize C-11 signal collection with a short PET acquisition. In comparison with the 50% pick-off technique, the shift technique is more robust and offers better precision in measuring the proton range for the different phantoms. Range measurements from PET images acquired with minimal delay, and the shift technique demonstrates the ability to achieve <1.5 mm accuracy and precision in estimating proton range.