Polyacrylamide-based glycoconjugates as tools in glycobiology

被引：169
|
作者：
Bovin, NV [1 ]
机构：
[1] Russian Acad Sci, MM Shemyakin Bioorgan Chem Inst, Moscow 117871, Russia
来源：
GLYCOCONJUGATE JOURNAL | 1998年 / 15卷 / 05期
关键词：
antibodies; assays; carbohydrates; cytochemistry; diagnostics; glycoconjugates; glycosyltransferases; histochemistry; immunoassay; lectins; polyacrylamide;
D O I：
10.1023/A:1006963717646
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review describes the synthesis, physicochemical characteristics and application for studying carbohydrate-binding proteins of polyacrylamide (PAA) type neoglycoconjugates. An approach to the synthesis of conjugates based on the interaction of activated polyacrylic acid with omega-aminoalkyl glycosides has been developed. Both the molecules of Glyc-PAA and the conjugates bearing various labels and effecters, as well as sorbents, and glycosurfaces can be designed using this method. Examples of the application of the conjugates as tools for the study of lectins, antibodies, and glycosyltransferases in glycobiology, cytochemistry and histochemistry are described along with the prospects of the further development of the presented approach in glycotechnology and medicine.
引用
收藏
页码：431 / 446
页数：16
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