Protein-PCNA interactions: a DNA-scanning mechanism?

被引：132

作者：

Kelman, Z ^{[1
]}

Hurwitz, J ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Biol Mol, New York, NY 10021 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(98)01223-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates.

引用

页码：236 / 238

页数：3

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