Synthesis of γ-hydroxy α,β-unsaturated amides by base-induced isomerization of epoxy amides

被引:10
作者
Brooks, PB [1 ]
Marson, CM [1 ]
机构
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
关键词
D O I
10.1016/S0040-4020(98)00519-5
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Treatment of 3,4-epoxyamides with LDA affords gamma-hydroxy-alpha,beta-unsaturated amides, usually with high (E)-selectivity. The 3,4-epoxyamides were prepared by the epoxidation of beta,gamma-unsaturated amides with meta-chloroperbenzoic acid. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:9613 / 9622
页数:10
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