MICROtransplant to refractory acute myeloid leukemia in Egyptian population

被引：6

作者：

Emarah, Ziad ^{[1
,2
]}

Shamaa, Sameh ^{[1
,2
]}

El-Zaafarany, Maha ^{[1
,2
]}

Eisa, Noha ^{[3
,4
]}

Khalaf, Mohamed ^{[5
]}

机构：

[1] Mansoura Univ, Fac Med, Dept Internal Med, Med Oncol Unit, Mansoura, Egypt

[2] Mansoura Univ, Ctr Oncol, Dept Oncol, Med Oncol Unit, Mansoura, Egypt

[3] Mansoura Univ, Fac Med, Dept Internal Med, Clin Hematol Unit, Mansoura, Egypt

[4] Mansoura Univ, Ctr Oncol, Dept Oncol, Clin Hematol Unit, Mansoura, Egypt

[5] Maadi Armed Forces Med Compound, Hematol & Oncol Hosp, Hematol & Stem Cell Transplantat Dept, Cairo, Egypt

来源：

CURRENT OPINION IN HEMATOLOGY | 2019年 / 26卷 / 06期

关键词：

cellular immunotherapy; haploidentical; microtransplantation; STEM-CELL TRANSPLANTATION; CHEMOTHERAPY; MOBILIZATION;

D O I：

10.1097/MOH.0000000000000547

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review The purpose of this review is to outline Egyptian experience of nonengraftment haploidentical cellular therapy [microtransplantation (MST)] for patients with refractory acute myeloid leukemia. Recent findings The use of granulocyte colony-stimulating factor primed halo-identical MST appears to be a biologically active therapy in patients with refractory acute myeloid leukemia (AML), especially in patients received less than four previous chemotherapy lines, fludarabine-free previous chemotherapy, response naive and young age patients. Refractory AML is still challenging. MST is promising, however the optimum conditioning, stem-cell dose, matching degree are factors should be optimized.

引用

页码：379 / 385

页数：7

共 13 条

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