MICROtransplant to refractory acute myeloid leukemia in Egyptian population

被引：6
作者：
Emarah, Ziad [1 ,2 ]
Shamaa, Sameh [1 ,2 ]
El-Zaafarany, Maha [1 ,2 ]
Eisa, Noha [3 ,4 ]
Khalaf, Mohamed [5 ]
机构：
[1] Mansoura Univ, Fac Med, Dept Internal Med, Med Oncol Unit, Mansoura, Egypt
[2] Mansoura Univ, Ctr Oncol, Dept Oncol, Med Oncol Unit, Mansoura, Egypt
[3] Mansoura Univ, Fac Med, Dept Internal Med, Clin Hematol Unit, Mansoura, Egypt
[4] Mansoura Univ, Ctr Oncol, Dept Oncol, Clin Hematol Unit, Mansoura, Egypt
[5] Maadi Armed Forces Med Compound, Hematol & Oncol Hosp, Hematol & Stem Cell Transplantat Dept, Cairo, Egypt
来源：
CURRENT OPINION IN HEMATOLOGY | 2019年 / 26卷 / 06期
关键词：
cellular immunotherapy; haploidentical; microtransplantation; STEM-CELL TRANSPLANTATION; CHEMOTHERAPY; MOBILIZATION;
D O I：
10.1097/MOH.0000000000000547
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of review The purpose of this review is to outline Egyptian experience of nonengraftment haploidentical cellular therapy [microtransplantation (MST)] for patients with refractory acute myeloid leukemia. Recent findings The use of granulocyte colony-stimulating factor primed halo-identical MST appears to be a biologically active therapy in patients with refractory acute myeloid leukemia (AML), especially in patients received less than four previous chemotherapy lines, fludarabine-free previous chemotherapy, response naive and young age patients. Refractory AML is still challenging. MST is promising, however the optimum conditioning, stem-cell dose, matching degree are factors should be optimized.
引用
收藏
页码：379 / 385
页数：7
相关论文
共 13 条
  • [1] Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia
    Cheson, BD
    Bennett, JM
    Kopecky, KJ
    Büchner, T
    Willman, CL
    Estey, EH
    Schiffer, CA
    Döhner, H
    Tallman, MS
    Lister, TA
    LoCocco, F
    Willemze, R
    Biondi, A
    Hiddemann, W
    Larson, RA
    Löwenberg, B
    Sanz, MA
    Head, DR
    Ohno, R
    Bloomfield, CD
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (24) : 4642 - 4649
  • [2] Nonengraftment Haploidentical Cellular Immunotherapy for Refractory Malignancies: Tumor Responses without Chimerism
    Colvin, Gerald A.
    Berz, David
    Ramanathan, Muthalagu
    Winer, Eric S.
    Fast, Loren
    Elfenbein, Gerald J.
    Quesenberry, Peter J.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2009, 15 (04) : 421 - 431
  • [3] Hematopoietic Stem-Cell Transplantation for Acute Leukemia in Relapse or Primary Induction Failure
    Duval, Michel
    Klein, John P.
    He, Wensheng
    Cahn, Jean-Yves
    Cairo, Mitchell
    Camitta, Bruce M.
    Kamble, Rammurti
    Copelan, Edward
    de Lima, Marcos
    Gupta, Vikas
    Keating, Armand
    Lazarus, Hillard M.
    Litzow, Mark R.
    Marks, David I.
    Maziarz, Richard T.
    Rizzieri, David A.
    Schiller, Gary
    Schultz, Kirk R.
    Tallman, Martin S.
    Weisdorf, Daniel
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (23) : 3730 - 3738
  • [4] HLA-Mismatched Stem-Cell Microtransplantation As Postremission Therapy for Acute Myeloid Leukemia: Long-Term Follow-Up
    Guo, Mei
    Hu, Kai-Xun
    Liu, Guang-Xian
    Yu, Chang-Lin
    Qiao, Jian-Hui
    Sun, Qi-Yun
    Qiao, Jun-Xiao
    Dong, Zheng
    Sun, Wan-Jun
    Sun, Xue-Dong
    Zuo, Hong-Li
    Man, Qiu-Hong
    Liu, Zhi-Qing
    Liu, Tie-Qiang
    Zhao, Hong-Xia
    Huang, Ya-Jing
    Wei, Li
    Liu, Bing
    Wang, Juan
    Shen, Xu-Liang
    Ai, Hui-Sheng
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (33) : 4084 - 4090
  • [5] Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients
    Guo, Mei
    Hu, Kai-Xun
    Yu, Chang-Lin
    Sun, Qi-Yun
    Qiao, Jian-Hui
    Wang, Dan-Hong
    Liu, Guang-Xian
    Sun, Wan-Jun
    Wei, Li
    Sun, Xue-Dong
    Huang, Ya-Jing
    Qiao, Jun-Xiao
    Dong, Zheng
    Ai, Hui-Sheng
    [J]. BLOOD, 2011, 117 (03) : 936 - 941
  • [6] Failure of three novel regimens to improve outcome for patients with relapsed or refractory acute myeloid leukaemia: a report from the Eastern Cooperative Oncology Group
    Litzow, Mark R.
    Othus, Megan
    Cripe, Larry D.
    Gore, Steven D.
    Lazarus, Hillard M.
    Lee, Sandra J.
    Bennett, John M.
    Paietta, Elisabeth M.
    Dewald, Gordon W.
    Rowe, Jacob M.
    Tallman, Martin S.
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2010, 148 (02) : 217 - 225
  • [7] Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?
    Morris, ES
    MacDonald, KPA
    Hill, GR
    [J]. BLOOD, 2006, 107 (09) : 3430 - 3435
  • [8] NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs
    Morris, ES
    MacDonald, KPA
    Rowe, V
    Banovic, T
    Kuns, RD
    Don, ALJ
    Bofinger, HM
    Burman, AC
    Olver, SD
    Kienzle, N
    Porcelli, SA
    Pellicci, DG
    Godfrey, DI
    Smyth, MJ
    Hill, GR
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) : 3093 - 3103
  • [9] Allogeneic stem-cell transplantation in patients with refractory acute leukemia:: a long-term follow-up
    Oyekunle, AA
    Kröger, N
    Zabelina, T
    Ayuk, F
    Schieder, H
    Renges, H
    Fehse, N
    Waschke, O
    Fehse, B
    Kabisch, H
    Zander, AR
    [J]. BONE MARROW TRANSPLANTATION, 2006, 37 (01) : 45 - 50
  • [10] Primary refractory acute myeloid leukaemia - in search of better definitions and therapies
    Ravandi, Farhad
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2011, 155 (04) : 413 - 419
12