Preclinical diagnosis of American visceral leishmaniasis during early onset of human Leishmania (L.) infantum chagasi-infection

被引：7

作者：

do Rego Lima, Luciana Vieira ^{[1
]}

Santos Ramos, Patricia Karla ^{[1
]}

Campos, Marliane Batista ^{[1
]}

dos Santos, Thiago Vasconcelos ^{[1
]}

de Castro Gomes, Claudia Maria ^{[2
]}

Laurenti, Marcia Dalastra ^{[2
]}

Pereira Corbett, Carlos Eduardo ^{[2
]}

Silveira, Fernando Tobias ^{[1
,3
]}

机构：

[1] Minist Hlth, Evandro Chagas Inst, Dept Parasitol Dept, Ananindeua, Para, Brazil

[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil

[3] Fed Univ Para, BR-66059 Belem, Para, Brazil

来源：

PATHOGENS AND GLOBAL HEALTH | 2014年 / 108卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Leishmania (L.) infantum chagasi; Human indeterminate initial infection; IgM-antibody response; Preclinical diagnosis; American visceral leishmaniasis; KALA-AZAR; IGM; SPECTRUM;

D O I：

10.1179/2047773214Y.0000000166

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

American visceral leishmaniasis (AVL) is an infectious disease, often with long-duration evolution, caused by Leishmania (L.) infantum chagasi. However, although the disease is considered the major clinical manifestation of the link between L. (L.) i. chagasi and the human immune response, we have recently identified five clinical-immunological profiles of infection in the Brazilian Amazon: three asymptomatic (Asymptomatic Infection - AI, Sub-clinical Resistant Infection - SRI, and Indeterminate Initial Infection III), and two symptomatic ones [Symptomatic Infection - SI (=AVL) and Sub-clinical Oligosymptomatic Infection - SOI]. We confirm here the preclinical diagnosis of AVL through the IgM-antibody response in a case of an early infection (profile III) that evolved to the full disease after 6 weeks.`

引用

页码：381 / 384

页数：4

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