Phthalocyanine-Peptide Conjugates via Palladium-Catalyzed Cross-Coupling Reactions

被引：25

作者：

Ali, Hasrat ^{[1
]}

Ait-Mohand, Samia ^{[1
]}

Gosselin, Simon ^{[1
]}

van Lier, Johan E. ^{[1
]}

Guerin, Brigitte ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Nucl Med & Radiobiol, CIMS, Sherbrooke, PQ J1H 5N4, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 06期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ARYL HALIDES; PORPHYRINS; AMIDATION; RECEPTORS; DESIGN; AMIDES; AGENT;

D O I：

10.1021/jo102083g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phthalocyanines (Pc) were conjugated with peptide moieties to improve their target selectivity for potential use as fluorescence and/or positron emission tomography (PET) probes in medical imaging. Three synthetic methods based on palladium-catalyzed cross-coupling reactions (Sonogashira, Buchwald-Hartwig, and Suzuki-Miyaura) were investigated. Using these methods, a series of peptides monofunctionalized with Pc at the N/C-terminal position or on a phenylalanine side chain was obtained in good yields and characterized.

引用

页码：1887 / 1890

页数：4

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