The mammalian Mediator complex and its role in transcriptional regulation

被引：236
作者：
Conaway, RC
Sato, S
Tomomori-Sato, C
Yao, TT
Conaway, JW [1 ]
机构：
[1] Stowers Inst Med Res, Kansas City, MO 64110 USA
[2] Univ Kansas, Med Ctr, Dept Biochem & Mol Biol, Kansas City, KS 66160 USA
[3] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2005年 / 30卷 / 05期
关键词：
D O I：
10.1016/j.tibs.2005.03.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of > 20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.
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收藏
页码：250 / 255
页数：6
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