The nationwide study of bacterial pathogens associated with urinary tract infections conducted by the Japanese Society of Chemotherapy

被引：38

作者：

Ishikawa, Kiyohito ^{[1
,7
]}

Matsumoto, Tetsuro ^{[1
,23
]}

Yasuda, Mitsuru ^{[1
,10
]}

Uehara, Shinya ^{[1
]}

Muratani, Tetsuro ^{[1
]}

Yagisawa, Morimasa ^{[1
]}

Sato, Junko ^{[1
]}

Niki, Yoshihito ^{[1
]}

Totsuka, Kyoichi ^{[1
]}

Sunakawa, Keisuke ^{[1
]}

Hanaki, Hideaki ^{[2
]}

Hattori, Rikizo ^{[1
]}

Terada, Michinori ^{[1
]}

Kozuki, Tsuneo ^{[1
]}

Maruo, Akinori ^{[1
]}

Morita, Kohei ^{[1
]}

Ogasawara, Kazuhiko ^{[1
]}

Takahashi, Yoshisaburo ^{[1
]}

Matsuda, Kenji ^{[1
]}

Hirose, Takaoki ^{[3
]}

Miyao, Noriomi ^{[4
]}

Hayashi, Tasuku ^{[4
]}

Takeyama, Koh ^{[5
]}

Kiyota, Hiroshi ^{[6
]}

Tomita, Masayuki ^{[6
]}

Yusu, Hisashi ^{[6
]}

Koide, Haruhisa ^{[6
]}

Kimura, Shoji ^{[6
]}

Yanaoka, Masanori ^{[8
]}

Sato, Hajime ^{[8
]}

Ito, Toru ^{[9
]}

Deguchi, Takashi ^{[10
]}

Fujimoto, Yoshinori ^{[11
]}

Komeda, Hisao ^{[11
]}

Asano, Yuko ^{[11
]}

Takahashi, Yoshito ^{[12
]}

Ishihara, Satoshi ^{[13
]}

Arakawa, Soichi ^{[14
]}

Nakano, Yuzo ^{[14
]}

Tanaka, Kazushi ^{[14
]}

Fujisawa, Masato ^{[14
]}

Matsui, Takashi ^{[15
]}

Fujii, Akira ^{[16
]}

Yamamoto, Shingo ^{[17
]}

Nojima, Michio ^{[17
]}

Higuchi, Yoshihide ^{[17
]}

Ueda, Yasuo ^{[17
]}

Kanamaru, Sojun ^{[18
]}

Monden, Koichi ^{[19
]}

Tsushima, Tomoyasu ^{[20
]}

机构：

[1] JSC, Bunkyo Ku, Tokyo 1130033, Japan

[2] Kitasato Univ, Tokyo, Japan

[3] Hokkaido Social Insurance Hosp, Sapporo, Hokkaido, Japan

[4] Muroran City Gen Hosp, Muroran, Hokkaido, Japan

[5] Hakodate Natl Hosp, Natl Hosp Org, Hakodate, Hokkaido, Japan

[6] Jikei Univ, Affiliated Aoto Hosp, Tokyo, Japan

[7] Fujita Hlth Univ, Aichi, Japan

[8] Japanese Red Cross Shizuoka Hosp, Shizuoka, Japan

[9] Nagoya Ekisaikai Hosp, Aichi, Japan

[10] Gifu Univ Hosp, Gifu, Japan

[11] Ogaki Municipal Hosp, Gifu, Japan

[12] Gifu Prefectural Gen Med Ctr, Gifu, Japan

[13] Kizawa Mem Hosp, Gifu, Japan

[14] Kobe Univ Hosp, Kobe, Hyogo, Japan

[15] Japanese Red Cross Kobe Hosp, Himeji, Hyogo, Japan

[16] Nippon Steel Hirohata Hosp, Himeji, Hyogo, Japan

[17] Hyogo Coll Med, Nishinomiya, Hyogo, Japan

[18] Nishi Kobe Med Ctr, Kobe, Hyogo, Japan

[19] Araki Urol Clin, Okayama, Japan

[20] Natl Hosp Org, Okayama Med Ctr, Okayama, Japan

[21] Okayama Citizens Hosp, Okayama, Japan

[22] Japanese Red Cross Okayama Hosp, Okayama, Japan

[23] Univ Occupat & Environm Hlth, Fukuoka, Japan

[24] Fukuoka Shin Mizumaki Hosp, Fukuoka, Japan

[25] Munakata Suikokai Gen Hosp, Fukuoka, Japan

[26] Ikei Hosp, Miyazaki, Japan

[27] Kagoshima Univ Hosp, Kagoshima, Japan

[28] Natl Hosp Org, Kagoshima Med Ctr, Kagoshima, Japan

[29] Tarumizu Chuo Hosp, Kagoshima, Japan

来源：

JOURNAL OF INFECTION AND CHEMOTHERAPY | 2011年 / 17卷 / 01期

关键词：

Surveillance; Drug susceptibility; Urinary tract infection; RESISTANT ESCHERICHIA-COLI; SPECTRUM BETA-LACTAMASES; TRIMETHOPRIM-SULFAMETHOXAZOLE; PSEUDOMONAS-AERUGINOSA; KLEBSIELLA-PNEUMONIAE; RISK-FACTORS; FLUOROQUINOLONE RESISTANCE; HOSPITALIZED-PATIENTS; WOMEN; PREVALENCE;

D O I：

10.1007/s10156-010-0174-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This study was conducted by the Japanese Society of Chemotherapy and is the first nationwide study on bacterial pathogens isolated from patients with urinary tract infections at 28 hospitals throughout Japan between January 2008 and June 2008. A total of 688 bacterial strains were isolated from adult patients with urinary tract infections. The strains investigated in this study are as follows: Enterococcus faecalis (n = 140), Escherichia coli (n = 255), Klebsiella pneumoniae (n = 93), Proteus mirabilis (n = 42), Serratia marcescens (n = 44), and Pseudomonas aeruginosa (n = 114). The minimum inhibitory concentrations of 39 antibacterial agents used for these strains were determined according to the Clinical and Laboratory Standards Institute (CLSI) manual. All Enterococcus faecalis strains were susceptible to ampicillin and vancomycin. Although a majority of the E. faecalis strains were susceptible to linezolid, 11 strains (7.8%) were found to be intermediately resistant. The proportions of fluoroquinolone-resistant Enterococcus faecalis, Escherichia coli, Proteus mirabilis, and S. marcescens strains were 35.7%, 29.3%, 18.3%, and 15.2%, respectively. The proportions of E. coli, P. mirabilis, K. pneumoniae, and S. marcescens strains producing extended-spectrum beta-lactamase were 5.1%, 11.9%, 0%, and 0%, respectively. The proportions of Pseudomonas aeruginosa strains resistant to carbapenems, aminoglycosides, and fluoroquinolones were 9.2%, 4.4%, and 34.8%, respectively, and among them, 2 strains (1.8%) were found to be multidrug resistant. These data present important information for the proper treatment of urinary tract infections and will serve as a useful reference for periodic surveillance studies in the future.

引用

页码：126 / 138

页数：13

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