Hypoxia-alleviated nanoplatform to enhance chemosensitivity and sonodynamic effect in pancreatic cancer

被引：28

作者：

Chen, Jifan ^{[1
,3
]}

Bao, Yuheng ^{[1
,2
,3
]}

Song, Yue ^{[1
,3
]}

Zhang, Cong ^{[1
,3
]}

Qiu, Fuqiang ^{[1
,3
]}

Sun, Yu ^{[1
,3
]}

Xin, Lei ^{[1
,3
]}

Cao, Jing ^{[1
,3
]}

Jiang, Yifan ^{[1
,3
]}

Luo, Jiali ^{[1
,3
]}

Zhang, Chao ^{[1
,3
]}

Wang, Guowei ^{[1
,3
]}

Li, Qunyin ^{[1
,3
]}

Liu, Yajing ^{[1
,3
]}

Tong, Weijun ^{[2
]}

Huang, Pintong ^{[1
,3
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Ultrasound Med, Hangzhou 310009, Peoples R China

[2] Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Minist Educ, Hangzhou 310007, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Res Ctr Ultrasound Med & Biomed Engn, Hangzhou 310009, Peoples R China

来源：

CANCER LETTERS | 2021年 / 520卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Nanozyme; Zeolitic imidazolate frameworks-90; Sonodynamic therapy; Pancreatic ductal cell carcinoma; PHOTODYNAMIC THERAPY; NANOPARTICLES; GEMCITABINE;

D O I：

10.1016/j.canlet.2021.07.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is a severe disease that threatens human health. The hypoxic tumor microenvironment in pancreatic cancer leads to resistance to conventional therapies and helps to maintain tumor malignancy. Firstline drugs present the disadvantage of systemic side effects, and a synergistic method with sonodynamic therapy (SDT) has been established as an emerging approach. In this study, we produced hypoxia-alleviating nanoplatforms (denoted as PZGI NPs) with zeolitic imidazolate frameworks-90 (ZIF-90) nanoparticles nucleating on platinum (Pt) nanoparticles and co-loaded with gemcitabine and IR780. This platform can catalyze peroxide to oxygen with loaded Pt nanoparticles to alleviate tumor hypoxia. Moreover, the loaded drugs could be quickly released in the lysosome microenvironment, which has a low pH value and high ATP level microenvironment in the mitochondria. This strategy could enhance the sensitivity of cancer cells to chemotherapy. Further, under ultrasound exposure, it could transfer the produced oxygen into a highly cytotoxic singlet oxygen for the augmented sonodynamic effect. Therefore, this multifunctional hypoxia-alleviating nanoplatform offers a promising strategy for chemo-sonodynamic therapy against pancreatic cancer.

引用

页码：100 / 108

页数：9

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