The definition of tuberculosis infection based on the spectrum of tuberculosis disease

被引:89
作者
Migliori, Giovanni Battista [1 ]
Ong, Catherine W. M. [2 ,3 ]
Petrone, Linda [4 ]
D'Ambrosio, Lia [5 ]
Centis, Rosella [1 ]
Goletti, Delia [4 ]
机构
[1] Ist Clin Sci Maugeri IRCCS, Serv Epidemiol Clin Malattie Resp, Tradate, Italy
[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore
[3] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore, Singapore
[4] Natl Inst Infect Dis Lazzaro Spallanzani IRCCS, Translat Res Unit, Rome, Italy
[5] Publ Hlth Consulting Grp, Lugano, Switzerland
关键词
SKIN-TEST; TB; DIAGNOSIS; COVID-19; COUGH; BLOOD; CELLS; ASSAY; PLUS;
D O I
10.1183/20734735.0079-2021
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Latent tuberculosis infection was the term traditionally used to indicate tuberculosis (TB) infection. This term was used to define "a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens through tests such as the tuberculin skin test (TST) or an interferon-gamma release assay (IGRA) without clinically active TB". Recent evidence indicates that the spectrum from TB infection to TB disease is much more complex, including a "continuum" of situations didactically reported as uninfected individual, TB infection, incipient TB, subclinical TB without signs/symptoms, subclinical TB with unrecognised signs/symptoms, and TB disease with signs/symptoms. Recent evidence suggests that subclinical TB is responsible for important M. tuberculosis transmission. This review describes the different stages described above and their relationships. It also summarises the new developments in prevention, diagnosis and treatment of TB infection as well as their public health and policy implications.
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页数:12
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