Direct organocatalytic and highly enantio- and diastereoselective Mannich reactions of α-substituted α-cyanoacetates

被引：152

作者：

Poulsen, TB ^{[1
]}

Alemparte, C ^{[1
]}

Saaby, S ^{[1
]}

Bella, M ^{[1
]}

Jorgensen, KA ^{[1
]}

机构：

[1] Aarhus Univ, Ctr Catalysis, Dept Chem, Danish Natl Res Fdn, DK-8000 Aarhus, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 19期

关键词：

asymmetric catalysis; diastereoselectivity; enantioselectivity; Mannich bases; organocatalysis;

D O I：

10.1002/anie.200500144

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Metal-free catalysis: Highly functionalized molecules with two contiguous stereocenters are easily accessed in high yield with high enantio- and diastereoselectivity by using a commercially available organocatalyst ((DHQD)2PYR, see scheme). The easily removed Boc protecting group in the product is an added value to this method as an important tool in asymmetric synthesis. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2896 / 2899

页数：4

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