Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children

被引：65

作者：

Andorf, Sandra ^{[1
,2
]}

Borres, Magnus P. ^{[3
,4
]}

Block, Whitney ^{[1
,2
]}

Tupa, Dana ^{[1
,2
]}

Bollyky, Jennifer B. ^{[5
]}

Sampath, Vanitha ^{[1
,2
]}

Elizur, Arnon ^{[1
,2
]}

Lidholm, Jonas ^{[3
]}

Jones, Joseph E. ^{[6
]}

Galli, Stephen J. ^{[2
,7
,8
]}

Chinthrajah, Rebecca S. ^{[1
,2
]}

Nadeau, Kari C. ^{[1
,2
]}

机构：

[1] Stanford Univ, Dept Med, Div Pulm & Crit Care Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA

[3] Thermo Fisher Sci, Immunodiagnost, Uppsala, Sweden

[4] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden

[5] Stanford Univ, Dept Med, Div Gen Med, Stanford, CA 94305 USA

[6] Thermo Fisher Sci, Immunodiagnost, Kalamazoo, MI USA

[7] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[8] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2017年 / 5卷 / 05期

关键词：

Multifood allergy; Component-resolved testing; IgE; Double-blind; placebo-controlled food challenge; ARA H 2; FOOD ALLERGY; CROSS-REACTIVITY; NATIONAL-HEALTH; PISTACHIO ALLERGY; PEANUT ALLERGENS; IN-VITRO; TREE NUT; PREVALENCE; IGE;

D O I：

10.1016/j.jaip.2017.01.016

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

BACKGROUND: Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. OBJECTIVE: We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs). METHODS: Sixty participants with multiple food allergies were characterized by clinical history, DBPCFCs, total IgE, specific IgE, and component-resolved diagnostics (IgE and IgG4) data. The food allergens tested were almond, egg, milk, sesame, peanut, pecan, walnut, hazelnut, cashew, pistachio, soy, and wheat. RESULTS: Our data demonstrate that of the reactions observed during a graded DBPCFC, gastrointestinal reactions occurred more often in boys than in girls, as well as in individuals with high levels of IgE to 2S albumins from cashew, walnut, and hazelnut. Certain food allergies often occurred concomitantly in individuals (ie, cashew/pistachio and walnut/pecan/hazelnut). IgE testing to components further corroborated serological relationships between and among these clustered food allergies. CONCLUSIONS: Associations of certain food allergies were shown by DBPCFC outcomes as well as by correlations in IgE reactivity to structurally related food allergen components. Each of these criteria independently demonstrated a significant association between allergies to cashew and pistachio, as well as among allergies to walnut, pecan, and hazelnut. (C) 2017 American Academy of Allergy, Asthma & Immunology

引用

页码：1325 / +

页数：14

共 40 条

[1] Prevalences of positive skin test responses to 10 common allergens in the US population: Results from the Third National Health and Nutrition Examination Survey [J].