Update on novel pharmacological therapies for osteoarthritis

被引:82
作者
Ghouri, Asim [1 ,3 ]
Conaghan, Philip G. [1 ,2 ]
机构
[1] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Chapeltown Rd, Leeds LS7 4SA, W Yorkshire, England
[2] Chapel Merton Hosp, NIHR Leeds Biomed Res Ctr, Chapeltown Rd, Leeds LS7 4SA, W Yorkshire, England
[3] NIHR Leeds Biomed Res Ctr, Leeds, W Yorkshire, England
关键词
cartilage; corticosteroids; DMOAD; inflammation; nociceptive pain; osteoarthritis; synovitis; INTERLEUKIN-1 RECEPTOR ANTAGONIST; RANDOMIZED CONTROLLED-TRIAL; VARIABLE DOMAIN IMMUNOGLOBULIN; BONE-MARROW LESIONS; NERVE GROWTH-FACTOR; TOLL-LIKE RECEPTORS; KNEE OSTEOARTHRITIS; DOUBLE-BLIND; TRIAMCINOLONE ACETONIDE; INTRAARTICULAR INJECTION;
D O I
10.1177/1759720X19864492
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Osteoarthritis (OA) is a chronic painful arthritis with increasing global prevalence. Current management involves non-pharmacological interventions and commonly used pharmacological treatments that generally have limited analgesic efficacy and multiple side effects. New treatments are therefore required to relieve patient symptoms and disease impact. A number of existing pharmacological therapies have been recently trialled in OA. These include extended-release triamcinolone and conventional disease-modifying anti-rheumatic drugs (DMARDs) used in the management of rheumatoid arthritis; generally, DMARDs have not shown a benefit in treating OA. Novel analgesic therapies are in development, including those targeting peripheral pain pathways. Disease-modifying osteoarthritis drugs (DMOADs) target key tissues in the OA pathophysiology process and aim to prevent structural progression; a number of putative DMOADs are in phase II development. There is preliminary evidence of structural improvement with some of these therapies but without concomitant symptom improvement, raising new considerations for future DMOAD trials.
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页数:11
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