A Highly Efficient Gold(I)-Catalyzed Mukaiyama-Mannich Reaction of α-Amino Sulfones with Fluorinated Silyl Enol Ethers To Give β-Amino α-Fluorinated Ketones

被引：24
|
作者：
Hu, Xiao-Si [1 ]
Du, Yi [2 ]
Yu, Jin-Sheng [1 ]
Liao, Fu-Min [1 ]
Ding, Pei-Gang [1 ]
Zhou, Jian [1 ,3 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Shanghai 200032, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
SYNLETT | 2017年 / 28卷 / 16期
基金：
中国国家自然科学基金;
关键词：
Mukaiyama-Mannich reaction; fluorinated silyl enol ethers; amino sulfones; amino fluorinated ketones; gold catalysis; N-ALKOXYCARBONYLAMINO SULFONES; CATALYTIC SAKURAI REACTION; AZA-HENRY REACTION; DIFLUOROENOL SILYL; AMIDO SULFONES; ALDOL REACTION; ASYMMETRIC-SYNTHESIS; IN-SITU; ACYLIMINIUM IONS; P-TOLYLSULFONES;
D O I：
10.1055/s-0036-1588475
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ph3PAuOTf was identified as a powerful catalyst for the Mukaiyama-Mannich reaction of fluorinated silyl enol ethers with aamino sulfones. This provides ready access to beta-amino alpha-fluorinated ketones in good to excellent yields.
引用
收藏
页码：2194 / 2198
页数：5
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