CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain

被引：54

作者：

Kiguchi, Norikazu ^{[1
]}

Kobayashi, Yuka ^{[1
]}

Maeda, Takehiko ^{[1
]}

Saika, Fumihiro ^{[1
]}

Kishioka, Shiroh ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Pharmacol, Wakayama 6410012, Japan

来源：

NEUROSCIENCE LETTERS | 2010年 / 484卷 / 01期

关键词：

Chemokine; CCL3; CCR1; CCR5; Allodynia; Hyperalgesia; RECEPTORS; MICROGLIA; IMMUNE; MECHANISMS; CELLS; ACTIVATION; EXPRESSION; LIGATION; MORPHINE; NEURONS;

D O I：

10.1016/j.neulet.2010.07.085

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the involvement of spinal macrophage inflammatory protein-1 alpha (MIP-1 alpha), an inflammatory chemokine. in partial sciatic nerve ligation (PSL)-induced neuropathic pain in mice. PSL increased MIP-1 alpha mRNA levels as well as levels of the MIP-1 alpha receptor, CCR1, but not CCR5 in the spinal dorsal horn. PSL-induced tactile allodynia and thermal hyperalgesia were prevented by intrathecal (it) injection of a neutralizing antibody of MIP-1 alpha (2 ng). Recombinant MIP-1 alpha (10 pmol, it.) elicited long-lasting tactile allodynia and thermal hyperalgesia in naive mice These results suggest that peripheral nerve injury elicits the up-regulation of spinal MIP-1 alpha and CCR1 to participate in neuropathic pain (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：17 / 21

页数：5

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