Ferroptosis in COVID-19-related liver injury: A potential mechanism and therapeutic target

被引：19
作者：
Chen, Yunqing [1 ]
Xu, Yan [1 ]
Zhang, Kan [1 ]
Shen, Liang [2 ]
Deng, Min [1 ]
机构：
[1] Jiaxing Univ, Dept Infect Dis, Affiliated Hosp, Jiaxing, Peoples R China
[2] Jiaxing Univ, Dept Cardiol, Affiliated Hosp, Jiaxing, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷
关键词：
COVID-19; ferroptosis; liver; SARS-CoV-2; hyperferritinemia; NONALCOHOLIC FATTY LIVER; IRON-METABOLISM; CELL-DEATH; DISEASE; HEPATOTOXICITY; NECROSTATIN-1; DEFEROXAMINE; PROTECTS; HEALTH; NCOA4;
D O I：
10.3389/fcimb.2022.922511
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The outbreak and worldwide spread of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a threat to global public health. SARS-CoV-2 infection not only impacts the respiratory system but also causes hepatic injury. Ferroptosis, a distinct iron-dependent form of non-apoptotic cell death, has been investigated in various pathological conditions, such as cancer, ischemia/reperfusion injury, and liver diseases. However, whether ferroptosis takes part in the pathophysiological process of COVID-19-related liver injury has not been evaluated yet. This review highlights the pathological changes in COVID-19-related liver injury and presents ferroptosis as a potential mechanism in the pathological process. Ferroptosis, as a therapeutic target for COVID-19-related liver injury, is also discussed. Discoveries in these areas will improve our understanding of strategies to prevent and treat hepatic injuries caused by COVID-19.
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页数：9
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