Ferroptosis in COVID-19-related liver injury: A potential mechanism and therapeutic target

被引：19
作者：
Chen, Yunqing [1 ]
Xu, Yan [1 ]
Zhang, Kan [1 ]
Shen, Liang [2 ]
Deng, Min [1 ]
机构：
[1] Jiaxing Univ, Dept Infect Dis, Affiliated Hosp, Jiaxing, Peoples R China
[2] Jiaxing Univ, Dept Cardiol, Affiliated Hosp, Jiaxing, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷
关键词：
COVID-19; ferroptosis; liver; SARS-CoV-2; hyperferritinemia; NONALCOHOLIC FATTY LIVER; IRON-METABOLISM; CELL-DEATH; DISEASE; HEPATOTOXICITY; NECROSTATIN-1; DEFEROXAMINE; PROTECTS; HEALTH; NCOA4;
D O I：
10.3389/fcimb.2022.922511
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The outbreak and worldwide spread of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been a threat to global public health. SARS-CoV-2 infection not only impacts the respiratory system but also causes hepatic injury. Ferroptosis, a distinct iron-dependent form of non-apoptotic cell death, has been investigated in various pathological conditions, such as cancer, ischemia/reperfusion injury, and liver diseases. However, whether ferroptosis takes part in the pathophysiological process of COVID-19-related liver injury has not been evaluated yet. This review highlights the pathological changes in COVID-19-related liver injury and presents ferroptosis as a potential mechanism in the pathological process. Ferroptosis, as a therapeutic target for COVID-19-related liver injury, is also discussed. Discoveries in these areas will improve our understanding of strategies to prevent and treat hepatic injuries caused by COVID-19.
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页数：9
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共 95 条
  • [1] NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
    Alvarez, Samantha W.
    Sviderskiy, Vladislav O.
    Terzi, Erdem M.
    Papagiannakopoulos, Thales
    Moreira, Andre L.
    Adams, Sylvia
    Sabatini, David M.
    Birsoy, Kivanc
    Possemato, Richard
    [J]. NATURE, 2017, 551 (7682) : 639 - +
  • [2] COVID-19 and the liver: overview
    Amin, Mona
    [J]. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2021, 33 (03) : 309 - 311
  • [3] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
    Angeli, Jose Pedro Friedmann
    Schneider, Manuela
    Proneth, Bettina
    Tyurina, Yulia Y.
    Tyurin, Vladimir A.
    Hammond, Victoria J.
    Herbach, Nadja
    Aichler, Michaela
    Walch, Axel
    Eggenhofer, Elke
    Basavarajappa, Devaraj
    Radmark, Olof
    Kobayashi, Sho
    Seibt, Tobias
    Beck, Heike
    Neff, Frauke
    Esposito, Irene
    Wanke, Ruediger
    Foerster, Heidi
    Yefremova, Olena
    Heinrichmeyer, Marc
    Bornkamm, Georg W.
    Geissler, Edward K.
    Thomas, Stephen B.
    Stockwell, Brent R.
    O'Donnell, Valerie B.
    Kagan, Valerian E.
    Schick, Joel A.
    Conrad, Marcus
    [J]. NATURE CELL BIOLOGY, 2014, 16 (12) : 1180 - U120
  • [4] High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data
    Antonio Diaz, Luis
    Idalsoaga, Francisco
    Cannistra, Macarena
    Candia, Roberto
    Cabrera, Daniel
    Barrera, Francisco
    Soza, Alejandro
    Graham, Rondell
    Riquelme, Arnoldo
    Arrese, Marco
    Leise, Michael D.
    Pablo Arab, Juan
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2020, 26 (48) : 7693 - 7706
  • [5] Zinc and selenium supplementation in COVID-19 prevention and treatment: a systematic review of the experimental studies
    Balboni, Erica
    Zagnoli, Federico
    Filippini, Tommaso
    Fairweather-Tait, Susan J.
    Vinceti, Marco
    [J]. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY, 2022, 71
  • [6] Banchini Filippo, 2020, Acta Biomed, V91, pe2020013, DOI 10.23750/abm.v91i3.9826
  • [7] SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione
    Bartolini, Desiree
    Stabile, Anna Maria
    Bastianelli, Sabrina
    Giustarini, Daniela
    Pierucci, Sara
    Busti, Chiara
    Vacca, Carmine
    Gidari, Anna
    Francisci, Daniela
    Castronari, Roberto
    Mencacci, Antonella
    Di Cristina, Manlio
    Focaia, Riccardo
    Sabbatini, Samuele
    Rende, Mario
    Gioiello, Antimo
    Cruciani, Gabriele
    Rossi, Ranieri
    Galli, Francesco
    [J]. REDOX BIOLOGY, 2021, 45
  • [8] The use of deferoxamine infusions to enhance the response rate to interferon-alpha treatment of chronic viral hepatitis B
    Bayraktar, Y
    Koseoglu, T
    Sommer, C
    Kayhan, B
    Temizer, A
    Uzunalimoglu, B
    DeMaria, N
    VanThiel, DH
    [J]. JOURNAL OF VIRAL HEPATITIS, 1996, 3 (03) : 129 - 135
  • [9] Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling
    Bednash, Joseph S.
    Kagan, Valerian E.
    Englert, Joshua A.
    Farkas, Daniela
    Tyurina, Yulia Y.
    Tyurin, Vladimir A.
    Samovich, Svetlana N.
    Farkas, Laszlo
    Elhance, Ajit
    Johns, Finny
    Lee, Hyunwook
    Cheng, Lijun
    Majumdar, Abhishek
    Jones, Daniel
    Mejia, Oscar Rosas
    Ruane-Foster, Marisa
    Londino, James D.
    Mallampalli, Rama K.
    Robinson, Richard T.
    [J]. TRANSLATIONAL RESEARCH, 2022, 240 : 1 - 16
  • [10] The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
    Bersuker, Kirill
    Hendricks, Joseph M.
    Li, Zhipeng
    Magtanong, Leslie
    Ford, Breanna
    Tang, Peter H.
    Roberts, Melissa A.
    Tong, Bingqi
    Maimone, Thomas J.
    Zoncu, Roberto
    Bassik, Michael C.
    Nomura, Daniel K.
    Dixon, Scott J.
    Olzmann, James A.
    [J]. NATURE, 2019, 575 (7784) : 688 - +
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