One-Pot Synthesis of N-H-Free Pyrroles from Aldehydes and Alkynes

被引：20

作者：

Chen, Lai ^{[1
]}

Huo, Jing-Qian ^{[1
]}

Si, He-Long ^{[2
]}

Xu, Xin-Yu ^{[3
]}

Kou, Song ^{[1
]}

Mao, Jianyou ^{[3
]}

Zhang, Jin-Lin ^{[1
]}

机构：

[1] Hebei Agr Univ, Coll Plant Protect, Baoding 071001, Peoples R China

[2] Hebei Agr Univ, Coll Life Sci, Baoding 071001, Peoples R China

[3] Nanjing Tech Univ, Sch Chem & Mol Engn, Tech Inst Fluorochem TIF, Inst Adv Synth, Nanjing 211816, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DIRECT ARYLATION; POLYSUBSTITUTED PYRROLES; CYCLOADDITION; 2H-AZIRINES; DESIGN;

D O I：

10.1021/acs.orglett.1c01287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first base-mediated intermolecular cyclization of arylaldehydes and terminal arylacetylenes for the synthesis of a wide range of pyrroles in a single step has been described. The developed methodology used commercially available starting materials and tolerated a broad range of functional groups affording 2,3,5-triaryl-substituted-1H-pyrroles with good yields (up to 92% yield) under mild conditions. The possible mechanism was also discussed.

引用

页码：4348 / 4352

页数：5

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