An update on the prevalence trends in Southern Saudi Arabia

被引：11

作者：

Makkawi, Mohammed ^{[1
]}

Alasmari, Sultan ^{[1
]}

Hawan, Ali A. ^{[2
]}

Al Shahrani, Mesfer M. ^{[1
]}

Dera, Ayed A. ^{[1
]}

机构：

[1] King Khalid Univ, Fac Appl Med Sci, Dept Clin Lab Sci, Abha, Saudi Arabia

[2] Armed Forces Hosp, Dept Microbiol, Khamis Mushay, Saudi Arabia

来源：

SAUDI MEDICAL JOURNAL | 2021年 / 42卷 / 07期

关键词：

HPLC; thalassemia; sickle cell disease; hemoglobin abnormalities; GENETIC-COUNSELING PROGRAM; SICKLE-CELL-DISEASE; BETA-THALASSEMIA; DISORDERS;

D O I：

10.15537/smj.2021.42.7.20210273

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: To investigate trends in hemoglobinopathies following the establishment of a mandatory premarital screening program (MPMSP) in the southern region of Saudi Arabia, where they are considered highly predominant. Methods: A retrospective analysis was performed on data from 32,130 high-performance liquid chromatography (HPLC) tests between November 2017 and October 2020. The data was obtained from the Hematology section, Laboratory Department, Armed Forces Hospital, Southern Region. Results: Despite the establishment of the MPMSP, our data showed that sickle cell disease remains a predominant hemoglobinopathy accounting for more than 7% of total tests in Southern Saudi Arabia. Observed HPLC hemoglobin fractions among the tested population showed a reduction in Hb A mean indicating a high rate of hemoglobin abnormalities. In addition, the prevalence of hemoglobin variants, including sickle cell and thalassemia, was higher in the younger population born after the MPMSP than in older subjects. Conclusion: Even with the implementation of the MPMSP, hemoglobin abnormalities remain prevalent in southern Saudi Arabia. A longer time frame is recommended to verify the validity of the program.

引用

页码：784 / 789

页数：6

共 20 条

[1] Epidemiology of Thalassemia in Gulf Cooperation Council Countries: A Systematic Review [J].

Abu-Shaheen, Amani ;

Heena, Humariya ;

Nofal, Abdullah ;

Abdelmoety, Doaa A. ;

Almatary, Abdulrahman ;

Alsheef, Mohammed ;

AlFayyad, Isamme .

BIOMED RESEARCH INTERNATIONAL, 2020, 2020

[2] Distribution of hemoglobinopathy disorders in Saudi Arabia based on data from the premarital screening and genetic counseling program, 2011-2015 [J].

Alsaeed, Eman S. ;

Farhat, Ghada N. ;

Assiri, Abdullah M. ;

Memish, Ziad ;

Ahmed, Elawad M. ;

Saeedi, Mohammad Y. ;

Al-Dossary, Mishal F. ;

Bashawri, Hisham .

JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH, 2018, 7 :S41-S47

[3]

Ashley-Koch A, 2000, AM J EPIDEMIOL, V151, P839

[4]

Bravo-Urquiola Martha, 2004, Invest. clín, V45, P309

[5]

Cao A, 2010, GENET MED, V12, P61, DOI [10.1097/GIM.0b013e3181cd68ed, 10.1038/gim.2016.173]

[6] Antenatal screening for haemoglobinopathies: current status, barriers and ethics [J].

Chakravorty, Subarna ;

Dick, Moira C. .

BRITISH JOURNAL OF HAEMATOLOGY, 2019, 187 (04) :431-440

[7] Current Standards of Care and Long Term Outcomes for Thalassemia and Sickle Cell Disease [J].

Chonat, Satheesh ;

Quinn, Charles T. .

GENE AND CELL THERAPIES FOR BETA-GLOBINOPATHIES, 2017, 1013 :59-87

[8]

DAHLAWI HA, 2018, RUSSIAN J HEMATOLOGY, V63, P159

[9] Sickle cell disease [J].

Kato, Gregory J. ;

Piel, Frederic B. ;

Reid, Clarice D. ;

Gaston, Marilyn H. ;

Ohene-Frempong, Kwaku ;

Krishnamurti, Lakshmanan ;

Smith, Wally R. ;

Panepinto, Julie A. ;

Weatherall, David J. ;

Costa, Fernando F. ;

Vichinsky, Elliott P. .

NATURE REVIEWS DISEASE PRIMERS, 2018, 4

[10] Newborn screening for sickle cell disease in Europe: recommendations from a Pan-European Consensus Conference [J].

Lobitz, Stephan ;

Telfer, Paul ;

Cela, Elena ;

Allaf, Bichr ;

Angastiniotis, Michael ;

Backman Johansson, Carolina ;

Badens, Catherine ;

Bento, Celeste ;

Bouva, Marelle J. ;

Canatan, Duran ;

Charlton, Matthew ;

Coppinger, Cathy ;

Daniel, Yvonne ;

de Montalembert, Marianne ;

Ducoroy, Patrick ;

Dulin, Elena ;

Fingerhut, Ralph ;

Froemmel, Claudia ;

Garcia-Morin, Marina ;

Gulbis, Beatrice ;

Holtkamp, Ute ;

Inusa, Baba ;

James, John ;

Kleanthous, Marina ;

Klein, Jeannette ;

Kunz, Joachim B. ;

Langabeer, Lisa ;

Lapoumeroulie, Claudine ;

Marcao, Ana ;

Marin Soria, Jose L. ;

McMahon, Corrina ;

Ohene-Frempong, Kwaku ;

Perini, Jean-Marc ;

Piel, Frederic B. ;

Russo, Giovanna ;

Sainati, Laura ;

Schmugge, Markus ;

Streetly, Allison ;

Tshilolo, Leon ;

Turner, Charles ;

Venturelli, Donatella ;

Vilarinho, Laura ;

Yahyaoui, Rachel ;

Elion, Jacques ;

Colombatti, Raffaella .

BRITISH JOURNAL OF HAEMATOLOGY, 2018, 183 (04) :648-660

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