Highly regioselective palladium-catalyzed annulation reactions of heteroatom-substituted allenes for synthesis of condensed heterocycles

被引：33
|
作者：
Inamoto, K
Yamamoto, A
Ohsawa, K
Hiroya, K [1 ]
Sakamoto, T
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
[2] Tohoku Univ, Century COE Program 21st, Comprehens Res & Educ Ctr Planning Drug Dev & Cli, Sendai, Miyagi 9808578, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 11期
关键词：
palladium; annulation; allene; heterocycle; alkyl metal reagent;
D O I：
10.1248/cpb.53.1502
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We have developed a highly regioselective synthesis of heterocycles via palladium-catalyzed annulation reaction of heteroatom-substituted allenes. Various aryl halides were reacted and one regioisomer was observed exclusively in all reactions. In addition, subsequent functionalizations of annulated products were carried out using alkyl metal reagents, and the introduction of alkyl moieties was accomplished.
引用
收藏
页码：1502 / 1507
页数：6
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