Genetic variants in the MTHFR are not associated with fatty liver disease

被引：9

作者：

De Vincentis, Antonio ^{[1
]}

Mancina, Rosellina Margherita ^{[2
]}

Pihlajamaki, Jussi ^{[3
,4
]}

Mannist, Ville ^{[5
,6
]}

Petta, Salvatore ^{[7
]}

Dongiovanni, Paola ^{[8
]}

Fracanzani, Anna Ludovica ^{[8
,9
]}

Valenti, Luca ^{[9
,10
]}

Tavaglione, Federica ^{[1
,2
]}

Romeo, Stefano ^{[2
,11
,12
]}

Vespasiani-Gentilucci, Umberto ^{[1
]}

机构：

[1] Univ Campus Biomed Rome, Dept Internal Med & Geriatr, Via Alvaro Portillo 200, I-00128 Rome, Italy

[2] Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden

[3] Kuopio Univ Hosp, Clin Nutr & Obes Ctr, Kuopio, Finland

[4] Univ Eastern Finland, Dept Publ Hlth & Clin Nutr, Kuopio, Finland

[5] Univ Eastern Finland, Dept Med, Kuopio, Finland

[6] Kuopio Univ Hosp, Dept Med, Kuopio, Finland

[7] Univ Palermo, Dept Gastroenterol, Palermo, Italy

[8] Fdn IRCCS Ca Granda Osped Policlin Milano, Gen Med & Metab Dis, Milan, Italy

[9] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy

[10] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Transfus Med & Hematol, Translat Med, Milan, Italy

[11] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Clin Nutr Unit, Catanzaro, Italy

[12] Sahlgrens Univ Hosp, Cardiol Dept, Gothenburg, Sweden

来源：

LIVER INTERNATIONAL | 2020年 / 40卷 / 08期

关键词：

fatty liver disease; fibrosis; MTHFR; NAFLD; NASH; steatosis; RISK; STEATOHEPATITIS;

D O I：

10.1111/liv.14543

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The common missense sequence variants of methylenetetrahydrofolate reductase (MTHFR), rs1801131 (c.A1298C) and rs1801133 (c.C677T), favour the development of hyperhomocysteinemia and diminished DNA methylation. Previous studies, carried out in small series and with suboptimal characterization of the hepatic phenotype, tested the association of these genetic variants with fatty liver disease (FLD), with conflicting results. Here, we assessed the association of rs1801131 and rs1801133 with hepatic phenotype in the Liver Biopsy Cross-Sectional Cohort, a large cohort (n=1375 from Italy and 411 from Finland) of European individuals with suspect FLD associated with dysmetabolism. A total of 1786 subjects were analysed by ordinal regression analyses. The rs1801131 and the rs1801133 variants were not associated with steatosis, inflammation, ballooning or fibrosis. The present study suggests that changes in folate and methionine metabolism resulting from these 2 variants are not associated with a clinically significant impact on FLD in Europeans.

引用

页码：1934 / 1940

页数：7

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