An Efficient Synthesis of N-Substituted-3-aryl-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)propanamides by Four-component Reaction in Aqueous Medium

被引：9

作者：

Dou Guolan ^{[1
]}

Zhong Xiaoxing ^{[1
]}

Wang Deming ^{[1
]}

Shi Daqing ^{[2
]}

机构：

[1] China Univ Min & Technol, Sch Safety Engn, Xuzhou 221116, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2011年 / 29卷 / 11期

关键词：

amide; four-component reaction; aqueous medium; synthetic method; ONE-POT SYNTHESIS; METHYLENE-GAMMA-BUTYROLACTONES; DIELS-ALDER REACTIONS; AMIDE BOND FORMATION; 3-COMPONENT REACTION; MULTICOMPONENT REACTIONS; CLAISEN REARRANGEMENT; CATALYZED SYNTHESIS; COUPLING REAGENTS; CARBON-MONOXIDE;

D O I：

10.1002/cjoc.201180404

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and efficient synthesis of N-substituted-3-aryl-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)propanamides via four-component reaction of an aldehyde, amine, Meldrum's acid and 5,5-dimethylcyclo-hexane-1,3-dione in the presence of benzyltriethylammonium chloride (TEBAC) in aqueous medium is described. This method has the advantages of accessible starting materials, good yields, mild reaction conditions and eco-friendliness.

引用

页码：2368 / 2372

页数：5

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