Triethyl Phosphite/Benzoyl Peroxide Mediated Reductive Dealkylation ofO-Benzoylhydroxylamines: A Cascade Synthesis of Secondary Amides

被引：5

作者：

Aegurla, Balakrishna ^{[1
]}

Mandle, Ram D. ^{[1
]}

Shinde, Prasad G. ^{[2
]}

Parit, Ratan S. ^{[2
]}

Kamble, Sanjay P. ^{[1
]}

Sudalai, Arumugam ^{[1
]}

Senthilkumar, Beeran ^{[2
]}

机构：

[1] CSIR Natl Chem Lab, Chem Engn & Proc Dev Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

[2] CSIR Natl Chem Lab, Div Organ Chem, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 2020卷 / 27期

关键词：

O-Benzoylhydroxylamines; Amides; Cascade reactions; Redox reactions; Synthetic methods; PRACTICAL SYNTHESIS; DEBENZYLATION; AMINES; DEPROTECTION; AMIDATION;

D O I：

10.1002/ejoc.202000611

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new triethyl phosphite/benzoyl peroxide (BPO) mediated system has been developed for the synthesis of secondary amides with good to excellent yields in a single step. This unprecedented cascade process involves sequential reduction of N-O bond and benzoylation followed by dealkylation of N-C bond ofO-benzoylhydroxylamines (O-BHA). The methodology is versatile as it tolerates a variety of aromatic and aliphaticO-BHA as substrates to access secondary amides.

引用

页码：4235 / 4238

页数：4

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