Antiviral Activity of Acyl Derivatives of Betulin and Betulinic and Dihydroquinopimaric Acids

被引：12

作者：

Kazakova, O. B. ^{[1
]}

Smirnova, I. E. ^{[1
]}

Baltina, L. A. ^{[1
]}

Boreko, E. I. ^{[2
]}

Savinova, O. V. ^{[2
]}

Pokrovskii, A. G. ^{[3
]}

机构：

[1] Russian Acad Sci, Ufa Fed Res Ctr, Autonomous Struct Unit, Ufa Inst Chem, Ufa 450054, Russia

[2] Republican Res & Practice Ctr Epidemiol & Microbi, Minsk 220114, BELARUS

[3] Vector State Res Ctr Virol & Biotechnol, Koltsov 630059, Novosibirsk Obl, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2018年 / 44卷 / 06期

关键词：

triterpenoids; diterpenoids; betulin; quinopimaric acid; acylates; antiviral activity; PHARMACOLOGICAL PROSPECTS; BIOLOGICAL-ACTIVITY; LUPANE TERPENOIDS; GLYCYRRHIZIC ACID; INHIBITION; AGENTS; TYPE-1;

D O I：

10.1134/S1068162018050059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The paper reports on the synthesis of a series of acyl derivatives of betulin and dihydroquinopimaric acid and the study of their antiviral activity against influenza A virus (H7N1), herpes simplex virus type 1 (HSV-1), ECHO 6, and HIV-1 in comparison with the activity of the previously obtained acylates and original terpenoids. It has been demonstrated that acylated betulin and betulinic acid show no advantage in inhibiting the reproduction of all the tested viruses compared with the betulic acid, while structural modifications at positions C3 and C28 of the triterpene core led to some changes in the spectrum of antiviral activity. Modification of dihydroquinopimaric acid at position C4 increased the activity of this compound against influenza virus A (H7N1).

引用

页码：740 / 744

页数：5

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