The functional interface between Salmonella and its host cell:: opportunities for therapeutic intervention

被引：45

作者：

Patel, JC ^{[1
]}

Rossanese, OW ^{[1
]}

Galán, JE ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 11期

关键词：

D O I：

10.1016/j.tips.2005.09.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Salmonella is a facultative intracellular pathogen that causes diseases ranging from self-limiting enteritis to typhoid fever. This bacterium uses two type III secretion systems to deliver effector proteins directly into the host cell to promote infection and disease. Recent characterization of these virulence proteins and their host-cell targets is uncovering the molecular mechanisms of Salmonella pathogenesis and is revealing a picture of the atomic interface between this pathogen and its host. This level of analysis provides the possibility of designing novel therapeutics to disrupt infection and disease processes at the molecular level.

引用

页码：564 / 570

页数：7

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