Next-generation sequencing diagnosis of severe pneumonia from fulminant psittacosis with multiple organ failure: a case report and literature review

被引：69

作者：

Zhang, Heng ^{[1
]}

Zhan, Danting ^{[1
]}

Chen, Dandan ^{[1
]}

Huang, Weibin ^{[1
]}

Yu, Min ^{[1
]}

Li, Qiuwen ^{[1
]}

Marcos, Pedro J. ^{[2
]}

Tattevin, Pierre ^{[3
]}

Wu, Di ^{[1
]}

Wang, Lingwei ^{[1
]}

机构：

[1] Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp,Affiliated Hosp 1,Shenzhen, Clin Med Coll 2,Shenzhen Inst Resp Dis,Dept Resp, Shenzhen 518020, Peoples R China

[2] Univ Coruna UDC, Univ Hosp Complex A Coruna CHUAC, Inst Biomed Res A Coruna INIBIC, Pneumol Serv, La Coruna, Spain

[3] Pontchaillou Univ Hosp, Infect Dis & Intens Care Unit, Rennes, France

来源：

ANNALS OF TRANSLATIONAL MEDICINE | 2020年 / 8卷 / 06期

关键词：

Next-generation sequencing (NGS); Chlamydia psittaci (C. psittaci); severe pneumonia; multiple organ failure; COMMUNITY-ACQUIRED PNEUMONIA; CHLAMYDIA-PSITTACI;

D O I：

10.21037/atm.2020.03.17

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study includes a retrospective analysis of the diagnosis and treatment of a case of severe pneumonia from fulminant psittacosis with multiple organ failure. Next-generation sequencing (NGS) of the pathogen was conducted. The purpose of this study was to summarize the clinical, laboratory, and imaging characteristics of the case and to improve understanding of the value of NGS in the diagnosis of severe community-acquired pneumonia (CAP). Fulminant psittacosis can be manifested as severe pneumonia with rapid progression, acute respiratory distress syndrome, sepsis, and multiple organ failure. Imaging shows unilateral lung consolidation, which is difficult to differentiate from CAP caused by common pathogens. The NGS technology can early detect rare pathogens, thus reducing unnecessary use of antibiotics and shortening the course of the disease.

引用

页数：7

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