Synthesis of Novel 3-Acetyl-2-aminothiophenes and Investigation of their Behaviour in the Reaction with Vilsmeier-Haack Reagent

被引：13

作者：

Abdelwahab, Ahmed B. ^{[1
,2
]}

Hanna, Atef G. ^{[2
]}

Kirsch, Gilbert ^{[1
]}

机构：

[1] Lorraine Univ, SRSMC, 1 Blvd Arago, F-57070 Metz, France

[2] Natl Res Ctr, Chem Nat Cpds Dept, El Behoos St 33, Dokki 12622, Egypt

来源：

SYNTHESIS-STUTTGART | 2016年 / 48卷 / 17期

关键词：

Vilsmeier-Haack; Gewald's reaction; thieno[2,3-b]pyridine; Buchwald-Hartwig; cross coupling; FACILE SYNTHESIS; THIENOPYRIDINES; ACID;

D O I：

10.1055/s-0035-1561459

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Through an investigation into the behaviour of 3-acetyl-2-aminothiophene in the reaction with Vilsmeier-Haack reagent, an efficient method for the synthesis of 4-chlorothieno[2,3-b]pyridine derivatives has been established. Gewald's classical synthesis starting from cyanoacetone, ketones and elemental sulphur has been applied to produce the starting materials.

引用

页码：2881 / 2888

页数：8

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