Current concepts in metastatic carcinoma: a review of the literature

被引:0
作者
Heck, Robert K. [1 ]
Tobey, Devon R. [1 ]
机构
[1] Univ Tennessee, Hlth Sci Ctr, Campbell Clin, Dept Orthopaed Surg & Biomed Engn, Memphis, TN 38163 USA
来源
CURRENT ORTHOPAEDIC PRACTICE | 2022年 / 33卷 / 02期
关键词
carcinoma; metastatic; tumor; oncology; orthopaedic oncology; treatment; BONE-DISEASE; DIAGNOSTIC EVALUATION; SKELETAL METASTASES; CLINICAL-FEATURES; MANAGEMENT; PATHOPHYSIOLOGY; PATIENT; CANCER; TUMORS;
D O I
10.1097/BCO.0000000000001078
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Metastatic spread to the skeletal system is a leading cause of morbidity and mortality in patients with cancer. With improved diagnostic imaging, laboratory studies, and new treatments, life expectancy has improved in oncology patients. With this increase in survival, the overall healthcare burden of metastatic bone disease also has increased. Treatment of metastatic disease of bone should be multidisciplinary and provide local and systemic tumor control. The overall performance status of a patient, the presence or absence of multiple lesions, the anatomic site affected, and viscera involved will all influence surgical options. If a pathologic fracture or impending fracture is present, the treatment should be durable and expected to last for the life of the patient. This review summarizes current concepts in the diagnosis and management of metastatic bone cancer, including the clinical approach to new bone lesions in patients without a known primary carcinoma, as the origin of such tumors has a significant implication on skeletal events and overall prognoses.
引用
收藏
页码:113 / 119
页数:7
相关论文
共 32 条
[1]   External Validation of PATHFx Version 3.0 in Patients Treated Surgically and Nonsurgically for Symptomatic Skeletal Metastases [J].
Anderson, Ashley B. ;
Wedin, Rikard ;
Fabbri, Nicola ;
Boland, Patrick ;
Healey, John ;
Forsberg, Jonathan A. .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2020, 478 (04) :808-818
[2]  
Colello Michael J., 2020, Sarcoma, V2020, P5105196, DOI 10.1155/2020/5105196
[3]   Metastatic bone disease: clinical features, pathophysiology and treatment strategies [J].
Coleman, RE .
CANCER TREATMENT REVIEWS, 2001, 27 (03) :165-176
[4]   Clinical features of metastatic bone disease and risk of skeletal morbidity [J].
Coleman, Robert E. .
CLINICAL CANCER RESEARCH, 2006, 12 (20) :6243S-6249S
[5]   Fracture risk assessment and clinical decision making for patients with metastatic bone disease [J].
Damron, Timothy A. ;
Mann, Kenneth A. .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2020, 38 (06) :1175-1190
[6]   Stereotactic body radiation therapy in combination with systemic therapy for metastatic renal cell carcinoma: a prospective multicentre study [J].
Dengina, Natalia ;
Mitin, Timur ;
Gamayunov, Sergey ;
Safina, Sufia ;
Kreinina, Yuliya ;
Tsimafeyeu, Ilya .
ESMO OPEN, 2019, 4 (05)
[7]   A Novel Classification System for Spinal Instability in Neoplastic Disease An Evidence-Based Approach and Expert Consensus From the Spine Oncology Study Group [J].
Fisher, Charles G. ;
DiPaola, Christian P. ;
Ryken, Timothy C. ;
Bilsky, Mark H. ;
Shaffrey, Christopher I. ;
Berven, Sigurd H. ;
Harrop, James S. ;
Fehlings, Michael G. ;
Boriani, Stefano ;
Chou, Dean ;
Schmidt, Meic H. ;
Polly, David W. ;
Biagini, Roberto ;
Burch, Shane ;
Dekutoski, Mark B. ;
Ganju, Aruna ;
Gerszten, Peter C. ;
Gokaslan, Ziya L. ;
Groff, Michael W. ;
Liebsch, Norbert J. ;
Mendel, Ehud ;
Okuno, Scott H. ;
Patel, Shreyaskumar ;
Rhines, Laurence D. ;
Rose, Peter S. ;
Sciubba, Daniel M. ;
Sundaresan, Narayan ;
Tomita, Katsuro ;
Varga, Peter P. ;
Vialle, Luiz R. ;
Vrionis, Frank D. ;
Yamada, Yoshiya ;
Fourney, Daryl R. .
SPINE, 2010, 35 (22) :E1221-E1229
[8]   Thirty-day Outcomes After Surgery for Metastatic Bone Disease of the Extremities: An Analysis of the NSQIP Database [J].
Gallaway, Kathryn E. ;
Ahn, Junho ;
Callan, Alexandra K. .
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 2020, 28 (22) :E1014-E1019
[9]   Treatment of femoral metastases [J].
Gibbs, C. Parker, Jr. ;
Earles, Melissa M. .
CURRENT ORTHOPAEDIC PRACTICE, 2014, 25 (06) :549-553
[10]   Adjuvant zoledronic acid therapy for patients with early stage breast cancer: an updated systematic review and meta-analysis [J].
He, Mingfeng ;
Fan, Weidong ;
Zhang, Xianquan .
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2013, 6