Endocrine Disrupting Chemicals Interfere With Leydig Cell Hormone Pathways During Testicular Descent in Idiopathic Cryptorchidism

被引：10

作者：

Fenichel, Patrick ^{[1
,2
]}

Chevalier, Nicolas ^{[1
,2
]}

Lahlou, Najiba ^{[3
]}

Coquillard, Patrick ^{[4
]}

Wagner-Mahler, Kathy ^{[5
]}

Pugeat, Michel ^{[6
]}

Panaia-Ferrari, Patricia ^{[7
]}

Brucker-Davis, Francoise ^{[1
,2
]}

机构：

[1] Univ Hosp Nice, Dept Reprod Endocrinol, Nice, France

[2] Univ Nice Sophia Antipolis, UMR U1065, Inst Natl Rech Med, Nice, France

[3] Paris Descartes Univ, Hop Cochin, APHP, Dept Hormonol & Metab Disorders, Paris, France

[4] Nice Univ, INRA CNRS, Inst Sophia Agrobiotech, Nice, France

[5] CHU Lenval, Dept Pediat, Pediat Endocrinol, Nice, France

[6] Hosp Civils Lyon1, Federat Endocrinol, U1060 CaRMen, Inst Natl Rech Med, Bron, France

[7] Univ Hosp Nice, Dept Biochem, Nice, France

来源：

FRONTIERS IN ENDOCRINOLOGY | 2019年 / 9卷

关键词：

cryptorchidism; endocrine disrupting chemicals; testosterone; insulin like peptide 3; leydig cells; INSULIN-LIKE FACTOR-3; IN-UTERO EXPOSURE; BISPHENOL-A; CORD BLOOD; CONGENITAL CRYPTORCHIDISM; DEVELOPMENTAL EXPRESSION; DYSGENESIS SYNDROME; TESTIS DESCENT; BREAST-MILK; PEPTIDE;

D O I：

10.3389/fendo.2018.00786

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cryptorchidism, a frequent genital malformation in male newborn, remains in most cases idiopathic. On the basis of experimental, epidemiological, and clinical data, it has been included in the testicular dysgenesis syndrome and believed to be influenced, together with genetic and anatomic factors, by maternal exposure to endocrine disrupting chemicals (EDCs). Here, we analyze how EDCs may interfere with the control of testicular descent, which is regulated by two Leydig cell hormones, testosterone, and insulin like peptide 3 (INSL3).

引用

页数：8

共 11 条

[1] Assessment and Molecular Actions of Endocrine-Disrupting Chemicals That Interfere with Estrogen Receptor Pathways
Kerdivel, Gwenneg
Habauzit, Denis
Pakdel, Farzad
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013, 2013
[2] Is Testicular Germ Cell Cancer Estrogen Dependent? The Role of Endocrine Disrupting Chemicals
Fenichel, Patrick
Chevalier, Nicolas
ENDOCRINOLOGY, 2019, 160 (12) : 2981 - 2989
[3] Utilization of hormone responsive cell lines for identification of endocrine disrupting chemicals
Abassi, Yama
Jin, Can
Stampfl, Melinda
Xu, Xiao
Wang, Xiaobo
TOXICOLOGY LETTERS, 2013, 221 : S164 - S164
[4] Understanding the role of endocrine disrupting chemicals in testicular germ cell cancer: Insights into molecular mechanisms
Pang, Won-Ki
Kuznetsova, Ekaterina
Holota, Helene
De Haze, Angelique
Beaudoin, Claude
Volle, David H.
MOLECULAR ASPECTS OF MEDICINE, 2024, 99
[5] In vitro testicular toxicity of environmentally relevant endocrine-disrupting chemicals: 2D vs. 3D models of prepubertal Leydig TM3 cells
Sychrova, Eliska
Yawer, Affiefa
Laboha, Petra
Basu, Amrita
Dydowiczova, Aneta
Virmani, Ishita
Babica, Pavel
Sovadinova, Iva
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022, 93
[6] Testicular responsiveness to gonadotropic hormone in vitro and Leydig and Sertoli cell ultrastructure during pubertal development of male African catfish (Clarias gariepinus)
Schulz, RW
Lubberink, K
Zandbergen, MA
JanssenDommerholt, C
Peute, J
Goos, HJT
FISH PHYSIOLOGY AND BIOCHEMISTRY, 1996, 15 (03) : 243 - 254
[7] The Combined Influence of the Endocrine Disrupting Chemicals Bisphenol A and Benzophenone-3 on Follicular Maturation and Immune Cell Populations in the Ovaries of Offspring Exposed In Utero and during Lactation.
Krieger, Elisabeth
Kretschmer, Tobias
Howanski, Julia
Fink, Beate
Bauer, Mario
Fischer, Florence
Schumacher, Anne
Zenclussen, Ana Claudia
REPRODUCTIVE SCIENCES, 2024, 31 : 265A - 265A
[8] Deregulation of anti-Mullerian hormone/BMP and transforming growth factor-β pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice
Hussein, Nader
Lu, JieLi
Casse, Huguette
Fontaniere, Sandra
Morera, Anne-Marie
Guittot, Severine Mazaud
Calender, Alain
Di Clemente, Nathalie
Zhang, Chang X.
ENDOCRINE-RELATED CANCER, 2008, 15 (01) : 217 - 227
[9] Paper of the October Issue of Stem Cell Reviews and Reports Addresses a Role of Prenatal Exposure of Murine Testicular Stem Cells to Endocrine Disrupting Chemicals that Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Life
Ratajczak, Mariusz Z.
STEM CELL REVIEWS AND REPORTS, 2020, 16 (05) : 811 - 811
[10] Paper of the October Issue of Stem Cell Reviews and Reports Addresses a Role of Prenatal Exposure of Murine Testicular Stem Cells to Endocrine Disrupting Chemicals that Results in Defective Spermatogenesis, Reduced Fertility and Tumor Initiation in Adult Life
Mariusz Z. Ratajczak
Stem Cell Reviews and Reports, 2020, 16 : 811 - 811

← 1 2 →