Nucleic Acid i-Motif Structures in Analytical Chemistry

被引：59

作者：

Alba, Joan Josep ^{[1
]}

Sadurni, Anna ^{[1
]}

Gargallo, Raimundo ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, Marti & Franques 1-11, E-08028 Barcelona, Spain

来源：

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2016年 / 46卷 / 05期

关键词：

Bioanalytical; DNA; electrochemistry; i-motif; spectroscopy; CYTOSINE-RICH STRAND; CONFORMATIONAL SWITCH; PH CHANGES; GOLD NANOPARTICLES; DNA NANOMACHINE; ELECTROCHEMICAL SENSOR; HYPERSENSITIVE ELEMENT; CONJUGATED POLYMER; PROTON DETECTION; GENE-EXPRESSION;

D O I：

10.1080/10408347.2016.1143347

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Under the appropriate experimental conditions of pH and temperature, cytosine-rich segments in DNA or RNA sequences may produce a characteristic folded structure known as an i-motif. Besides its potential role in vivo, which is still under investigation, this structure has attracted increasing interest in other fields due to its sharp, fast and reversible pH-driven conformational changes. This on/off switch at molecular level is being used in nanotechnology and analytical chemistry to develop nanomachines and sensors, respectively. This paper presents a review of the latest applications of this structure in the field of chemical analysis.

引用

页码：443 / 454

页数：12

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