Supply chain risk management has emerged as an important issue in recent years, given more dynamic and turbulent business environments. This study investigates the impact of strategic sourcing, e-business technologies and supply chain integration on supply chain risk mitigation. Based on the theoretical background of dynamic capabilities, it also examines the role of business environment and characteristics. A structured survey methodology is used, collecting 152 responses from purchasing and supply management executives from US manufacturing industry. The results empirically confirm that strategic sourcing, e-business technologies and supply chain integration have a negative relationship with supply chain risk. The study also shows that if business environments are dynamic and competitive, more emphasis is found on implementing these three supply chain practices. It is also shown that business environments have a moderating effect on the relationships of strategic sourcing, e-business technologies and supply chain integration, with supply chain risk.